Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
SepM mutation in Streptococcus mutans clinical isolates and related function analysis.
BMC Oral Health
June 2024
Department of Biochemistry and Molecular Biology, Bengbu Medical College, 2600 Dong Hai Avenue, Bengbu, 233030, China.
Article Synopsis
- ) S. mutans is a bacterium that contributes to dental cavities, while S. gordonii helps inhibit its growth; the role of the SepM protein in enhancing S. mutans's inhibitory effects on S. gordonii was investigated.
- ) The study involved analyzing 286 clinical strains of S. mutans, distinguishing between those capable of inhibiting S. gordonii and those that could not, and looking for mutations in the sepM gene.
- ) Key findings revealed specific mutations (C482T, G533A, and G661A) were more common in the inhibitory strains, with some mutations leading to increased expression of important proteins involved in the bacteria's interaction, suggesting that these mutations enhance S. mut
Relationships between the inhibitory efficacy and physicochemical properties of six organic acids and monolaurin against Bacillus weihenstephanensis KBAB4 growth in liquid medium.
Food Microbiol
August 2024
Univ Brest, INRAE, Laboratoire Universitaire de Biodiversité et Écologie Microbienne, F-29000 Quimper, France. Electronic address:
Organic acids are widely used in foodstuffs to inhibit pathogen and spoiler growth. In this study, six organic acids (acetic, lactic, propionic, phenyllactic, caprylic, and lauric acid) and monolaurin were selected based on their physicochemical properties: their molecular structure (carbon chain length), their lipophilicity (logP), and their ability to dissociate in a liquid environment (pKa). The relation between these physicochemical properties and the inhibitory efficacy against B.
View Article and Find Full Text PDFElectrochemical Nanoreactor Provides a Comprehensive View of Isocitrate Dehydrogenase Cancer-drug Kinetics.
Angew Chem Weinheim Bergstr Ger
October 2023
The ability to control enzyme cascades entrapped in a nanoporous electrode material (the "Electrochemical Leaf", e-Leaf) has been exploited to gain detailed kinetic insight into the mechanism of an anti-cancer drug. Ivosidenib, used to treat acute myeloid leukemia, acts on a common cancer-linked variant of isocitrate dehydrogenase 1 (IDH1 R132H) inhibiting its "gain-of-function" activity-the undesired reduction of 2-oxoglutarate (2OG) to the oncometabolite 2-hydroxyglutarate (2HG). The e-Leaf quantifies the kinetics of IDH1 R132H inhibition across a wide and continuous range of conditions, efficiently revealing factors underlying the inhibitor residence time.
View Article and Find Full Text PDFA novel selective ERK1/2 inhibitor, Laxiflorin B, targets EGFR mutation subtypes in non-small-cell lung cancer.
Acta Pharmacol Sin
February 2024
Guangdong Key Laboratory of Genome Instability and Human Disease Prevention, International Cancer Center, Department of Cell Biology and Genetics, Shenzhen University Medical School; College of Life Sciences and Oceanography, Shenzhen University; Department of Pharmacy, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital (Shenzhen Institute of Translational Medicine), Shenzhen, 518055, China.
Extracellular regulated protein kinases 1/2 (ERK1/2) are key members of multiple signaling pathways, including the ErbB axis. Ectopic ERK1/2 activation contributes to various types of cancer, especially drug resistance to inhibitors of RTK, RAF and MEK, and specific ERK1/2 inhibitors are scarce. In this study, we identified a potential novel covalent ERK inhibitor, Laxiflorin B, which is a herbal compound with anticancer activity.
View Article and Find Full Text PDFMethanogenesis in biogas reactors under inhibitory ammonia concentration requires community-wide tolerance.
Appl Microbiol Biotechnol
November 2023
Thünen Institute for Biodiversity, Johann Heinrich von Thünen Institute, 38116, Braunschweig, Germany.
Ammonia (NH) inhibition represents a major limitation to methane production during anaerobic digestion of organic material in biogas reactors. This process relies on co-operative metabolic interactions between diverse taxa at the community-scale. Despite this, most investigations have focused singularly on how methanogenic Archaea respond to NH stress.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!