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Impact of cold plasma-assisted Non-thermal deamidation and glycosylation on the construction of sugar derivative-zein conjugates for enhancing pickering foam stability: Technical principles and molecular interactions.
Food Res Int
January 2025
State Key Laboratory of Food Nutrition and Safety, Key Laboratory of Food Nutrition and Safety, Ministry of Education, College of Food Science and Engineering, Tianjin University of Science & Technology, No. 9, No. 13 Ave., TEDA, Tianjin 300457, China. Electronic address:
There is an urgent need for stable, plant-based Pickering foams to address the growing consumer demand for sustainable, low-calorie, aerated sweet foods. This study employed a cold plasma-assisted deamidation and glycosylation (CPDG) approach to promote hydrophilic reassembly of zein, resulting in the formation of sugar derivative-zein conjugates. This was accomplished by coupling deamidated zein with polyhydroxy sugars including sucralose (Suc), maltitol (Mal), mannitol (Man), and stevioside (Ste).
View Article and Find Full Text PDFProlonged self-assembly of H. pylori ferritin globules at physiological conditions.
Biochem Biophys Res Commun
January 2025
Research Center for Molecular Mechanisms of Aging and Age-Related Diseases, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russian Federation; Frank Laboratory of Neutron Physics, Joint Institute for Nuclear Research, Dubna, 141980, Russian Federation. Electronic address:
One of the promising drug delivery tools is ferritin, which features high stability at a wide range of conditions and protects cargo by its spherical protein shell. We studied the self-assembly into homoglobules of ferritin from H. pylori and a chimeric protein ferritin-SUMO.
View Article and Find Full Text PDFNon-stochastic reassembly of a metabolically cohesive gut consortium shaped by N-acetyl-lactosamine-enriched fibers.
Gut Microbes
December 2025
Department of Plant and Microbial Biology, North Carolina State University, Raleigh, NC, USA.
Diet is one of the main factors shaping the human microbiome, yet our understanding of how specific dietary components influence microbial consortia assembly and subsequent stability in response to press disturbances - such as increasing resource availability (feeding rate) - is still incomplete. This study explores the reproducible re-assembly, metabolic interplay, and compositional stability within microbial consortia derived from pooled stool samples of three healthy infants. Using a single-step packed-bed reactor (PBR) system, we assessed the reassembly and metabolic output of consortia exposed to lactose, glucose, galacto-oligosaccharides (GOS), and humanized GOS (hGOS).
View Article and Find Full Text PDFMicrobial-induced reassembly of phosphate sol: New insight into the removal and fixation of divalent manganese in natural aquatic environment.
Chemosphere
February 2025
Institute of Urban Environment, Chinese Academy of Sciences, 1799th Jimei Road, Xiamen, 361021, China.
The commonly used precipitation method struggles to effectively remove low-concentration heavy metals from water. Herein, we demonstrate that the formation of non-settleable phosphate sols at a low low-concentration is the main reason by using phosphate precipitation as an example and report a new method called microbial-induced reassembly (MIR) of the phosphate sols for the removal and fixation of divalent manganese (Mn(II)) from low-concentration wastewater under neutral conditions. Under the induction of microorganisms, the Mn(PO) sols formed in low Mn(II) concentration could be reassembled into larger and flower-like precipitates with good settleability, allowing for the removal and fixation of low-concentration Mn(II) through natural settlement.
View Article and Find Full Text PDFIn situ self-reassembling nanosystem enhances PD-L1 blockade for cancer immunotherapy.
J Control Release
January 2025
School of Pharmaceutical Sciences, Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, Zhengzhou University, Zhengzhou 450001, China. Electronic address:
Although immune checkpoint inhibitors (ICIs) have made great progress in cancer treatment, their off-tumor distribution, low affinity of traditional ICIs and insufficient T cells infiltration at tumor site limit immunotherapeutic efficacy. Herein, we engineer a highly specific and effective PD-L1 inhibitor (PEC) that modulates the level of binding sites with PD-L1. Specifically, PEC is a hybrid system composed of E.
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