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The First Large Identification of 3ANX and NX Producing Isolates of in Manitoba, Western Canada.
Toxins (Basel)
January 2025
Manitoba Agriculture, 65-3rd Avenue NE, Carman, MB R1N 1Y7, Canada.
Fusarium head blight, caused by , continues to be one of the most important and devastating fungal diseases on cereal grains including wheat, barley, and oat crops. produces toxic secondary metabolites that include trichothecene type A and type B mycotoxins. There are many variants of these toxins that are produced, and in the early 2010s, a novel type A trichothecene mycotoxin known as 3ANX (7-α hydroxy,15-deacetylcalonectrin) and its deacetylated product NX (7-α hydroxy, 3,15-dideacetylcalonectrin) were identified in Minnesota, USA.
View Article and Find Full Text PDFTherapeutic potential of 3-acetyl coumarin against polycystic ovarian syndrome induced by letrozole using female rats.
Naunyn Schmiedebergs Arch Pharmacol
December 2024
Laboratory of Biotechnology and Natural Resources Valorization, Faculty of Sciences, Ibn Zohr University, 80060, Agadir, Morocco.
Polycystic ovarian syndrome is a heterogeneous endocrine disorder characterized by ovarian cysts, anovulation, endocrine variations, which includes oligo-amenorrhea along with associated subfertility and hyperandrogenism manifested as acne, hirsutism, and male-pattern alopecia. Coumarins are fused benzene and pyrone ring systems that exhibit a wide spectrum of bioactivities. This study aimed to investigate the effects of 3-acetyl coumarin (3-AC) on polycystic ovarian syndrome in female rats.
View Article and Find Full Text PDFThe evaluation of earwax as a noninvasive specimen to determine livestock exposure to death camas (Zigadenuspaniculatus).
Toxicon
December 2024
Poisonous Plant Research Laboratory, Agricultural Research Service, United States Department of Agriculture, 1150 E. 1400 N., Logan, UT 84341, USA.
Foothill death camas (Z. paniculatus) grows on the foothill ranges of western North America and is acutely toxic to livestock grazing these ranges. The toxic alkaloids in foothill death camas are zygadenine and a series of zygadenine esters, with zygacine, the 3-acetyl ester of zygadenine, being the most abundant.
View Article and Find Full Text PDFMultimodal antibacterial potency of newly designed and synthesized Schiff's/Mannich based coumarin derivatives: potential inhibitors of bacterial DNA gyrase and biofilm production.
RSC Adv
October 2024
Medicinal Chemistry Research Laboratory, School of Pharmaceutical Sciences, Siksha 'O' Anusandhan Deemed to be University Bhubaneswar 751003 Odisha India
The briskened urge to develop potential antibacterial candidates against multidrug-resistant pathogens has motivated the present research study. Herein, newly synthesized coumarin derivatives with azomethine and amino-methylated as the functional groups have been focused on their antibacterial efficacy. The study proposed two distinct series: 3-acetyl substituted coumarin derivatives, followed by the Schiff base approach (5a-5i), and formaldehyde-secondary cyclic amine-based derivatives (7a-7g), using the Mannich base approach, further the compounds have been confirmed through various spectral studies.
View Article and Find Full Text PDFComparison of the acute toxicity of zygacine versus zygadenine.
Toxicon
September 2024
USDA-ARS Poisonous Plant Research Laboratory, 1150 East 1400 North, Logan, UT, 84341, USA.
Foothill death camas (Zigadenus paniculatus) is a common poisonous plant found throughout western North America. The toxic alkaloids in foothill death camas are zygadenine, esters of zygadenine, with zygacine, the 3-acetyl ester of zygadenine, often being the most abundant. Two additional esters of zygadenine that are found primarily in the floral parts of foothill death camas are 3-angeloylzygadenine and 3-veratroylzygadeine.
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