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Niraparib Maintenance Therapy in Patients with Platinum-Sensitive Recurrent Ovarian Cancer: Real-World Experience at Hospitals in Spain.
Target Oncol
January 2025
Pharmacy Service, H. Móstoles, Madrid, Spain.
Background: The reported benefit of poly (ADP-ribose) polymerase inhibitor (PARPi) maintenance in patients with newly diagnosed and platinum (Pt)-sensitive recurrent ovarian cancer (OC) included in randomized clinical trials needs to be corroborated in a less selected population.
Objective: The aim is to increase the evidence on niraparib in a real-world setting.
Methods: This is a retrospective observational study including women with platinum-sensitive relapsed high-grade serous OC who started niraparib maintenance between August 2019 (marketing data, Spain) and May 2022.
Long-term impact of COVID-19-related nonpharmaceutical interventions on tuberculosis: an interrupted time series analysis using Bayesian method.
J Glob Health
January 2025
Beijing Key Laboratory of Antimicrobial Agents/Laboratory of Pharmacology, Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China.
Background: The implementation of non-pharmaceutical interventions (NPIs) during the COVID-19 pandemic may inadvertently influence the epidemiology of tuberculosis (TB). (TB). However, few studies have explored how NPIs impact the long-term epidemiological trends of TB.
View Article and Find Full Text PDFThe GacS/GacA two-component system strongly regulates antimicrobial competition mechanisms of MFE01 strain.
J Bacteriol
January 2025
Laboratoire de Communication Bactérienne et Stratégies Anti-infectieuses (CBSA UR4312, formerly LMSM EA4312), Univ Rouen Normandie, Université Caen Normandie, Normandie Univ, Rouen, France.
Unlabelled: MFE01 is an environmental bacterium characterized by an hyperactive type 6 secretion system (T6SS) and a strong emission of volatile organic compounds (VOCs). In a previous study, a transposition mutant, 3H5, exhibited an inactive T6SS and altered VOC emission. In 3H5, the interruption of gene by the transposon was insufficient to explain these phenotypes.
View Article and Find Full Text PDFSystematic Risk Analysis and Mitigation Strategies for Near-Miss Events in Interventional Operating Room Nursing.
Risk Manag Healthc Policy
January 2025
Department of Nursing, Affiliated Hospital 2 of Nantong University, Nantong, 226001, People's Republic of China.
Purpose: The aim of this study is to examine the characteristics of intraoperative nursing near-miss events in interventional operating rooms, systematically identify and analyze associated risks, and propose effective mitigation strategies.
Patients And Methods: A retrospective study was conducted using a specially designed survey focused on nursing near-miss events in Interventional operating rooms. Records of intraoperative near-miss events voluntarily reported by medical and nursing staff between January 2023 and March 2024 were analyzed.
Antagonism of CD28 blocks allergic responses in the ovalbumin-induced asthmatic model mice.
Int Immunopharmacol
January 2025
Allergen-reactive T helper (Th) 2 cells play a pivotal role in initiating asthma pathogenesis. The absence or interruption of CD28 signaling causes significant consequences for T-cell activation, leading to reduced cell proliferation and interleukin (IL)-2 production. A novel compound, Cyn-1324, exhibits a higher binding affinity to CD28 than CD80.
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