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TFII-I/GTF2I regulates globin gene expression and stress response in erythroid cells.
J Biol Chem
January 2025
Department of Biochemistry and Molecular Biology, College of Medicine, Center for Epigenetics, Genetics Institute, UF Health Cancer Center, Powell-Gene Therapy Center, University of Florida, Gainesville, Florida 32610. Electronic address:
Transcription factor TFII-I/GTF2I is ubiquitously expressed and has been shown to play a role in the differentiation of hematopoietic cells and in the response to various cellular stressors. We previously demonstrated that TFII-I acts as a repressor of adult β-globin gene transcription and positively regulates expression of stress response proteins, including ATF3. Here we analyzed the function of TFII-I in TF-1 cells during erythroid differentiation and in response to cellular stress, including unfolded protein response, hypoxia, and oxidative stress.
View Article and Find Full Text PDFErythropoietin Production in Embryonic Neural Cells is Controlled by Hypoxia Signaling and Histone Deacetylases with an Undifferentiated Cellular State.
Mol Cell Biol
January 2025
Applied Oxygen Physiology Project, New Industry Creation Hatchery Center, Tohoku University, Sendai, Japan.
During mammalian development, production sites of the erythroid growth factor erythropoietin (EPO) shift from the neural tissues to the liver in embryos and to the kidneys in adults. Embryonic neural EPO-producing (NEP) cells, a subpopulation of neuroepithelial and neural crest cells, express the gene between embryonic day (E) 8.5 and E11.
View Article and Find Full Text PDFChorioamnionitis and Two-Year Outcomes in Infants with Hypoxic-Ischemic Encephalopathy.
J Pediatr
December 2024
Division of Neonatology, Department of Pediatrics, Fetal Neonatal Institute, Children's Hospital Los Angeles, Keck School of Medicine University of Southern California, Los Angeles, CA.
Objective: To determine if chorioamnionitis is associated with an increased risk of adverse 2-year outcomes among infants with hypoxic-ischemic encephalopathy (HIE).
Study Design: This cohort study included all infants with moderate to severe HIE treated with therapeutic hypothermia and enrolled on the High-dose Erythropoietin for Asphyxia and Encephalopathy Trial. Clinical chorioamnionitis (CC) was defined as a diagnosis made by a treating obstetrician and histologic chorioamnionitis (HC) was defined as placental inflammation observed on histology.
A practical guide to reducing/eliminating red blood cell transfusions in the neonatal intensive care unit.
Semin Fetal Neonatal Med
October 2024
Division of Neonatology, Department of Pediatrics, University of Utah, 295 Chipeta Way, Salt Lake City, UT, 84108, USA; Women and Newborns Research, Intermountain Health, Murray, UT, USA.
Article Synopsis
- * Common risks include worsening inflammatory issues and potential long-term effects like retinopathy of prematurity and neurodevelopmental delays, which are sometimes not fully addressed during the informed consent process.
- * Implementing non-drug methods to avoid transfusions, alongside erythropoietic stimulating agents, can significantly reduce the need for transfusions in NICU patients, making care both more effective and cost-efficient.
Association of delayed cord clamping with acute kidney injury and two-year kidney outcomes in extremely premature neonates: a secondary analysis of the preterm erythropoietin neuroprotection trial (PENUT).
J Perinatol
January 2025
University of Wisconsin, Division of Neonatology, Madison, WI, USA.
Article Synopsis
- Delayed cord clamping (DCC) is a common practice during preterm births, but its effects on kidney health are uncertain.
- A study evaluated DCC against early cord clamping (ECC) in preterm infants, focusing on acute kidney injury (AKI) and kidney function at two years.
- Findings indicated that DCC did not reduce the risk of AKI but was linked to a significantly higher chance of reduced kidney function (eGFR <90 mL/min/1.73m) after two years.
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