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Intra-articular therapy in osteoarthritis.
Postgrad Med J
August 2003
Department of Internal Medicine, Faculty of Medicine, American University of Beirut, Beirut, Lebanon.
The medical literature was reviewed from 1968-2002 using Medline and the key words "intra-articular" and "osteoarthritis" to determine the various intra-articular therapies used in the treatment of osteoarthritis. Corticosteroids and hyaluronic acid are the most frequently used intra-articular therapies in osteoarthritis. Other intra-articular substances such as orgotein, radiation synovectomy, dextrose prolotherapy, silicone, saline lavage, saline injection without lavage, analgesic agents, non-steroidal anti-inflammatory drugs, glucosamine, somatostatin, sodium pentosan polysulfate, chloroquine, mucopolysaccharide polysulfuric acid ester, lactic acid solution, and thiotepa cytostatica have been investigated as potentially therapeutic in the treatment of arthritic joints.
View Article and Find Full Text PDFIntra-articular injection of thiotepa in the treatment of rheumatoid arthritis of the digital joints.
J Hand Surg Am
May 1995
Hospital Ortopédico, Belo Horizonte, Brazil.
Seventy-five patients with rheumatoid arthritis (RA) were reviewed 9 years after an extensive evaluation which included quantitative measures of functional capacity. These patients had received multiple intraarticular injections of thiotepa with corticosteroids early in their course, but appear demographically and functionally similar to other RA patients who had not received this therapy. Severe morbidity was seen over the 9-year period in the 55 surviving patients, including significantly lower overall functional capacity in 92% of patients studied, lower grip strength in 93%, and longer button test results in 84%.
View Article and Find Full Text PDFIs there a place for chemical and radiation synovectomy in rheumatic diseases?
Rheumatol Rehabil
May 1979
Synoviorthesis has the same indications as surgical synovectomy. But it is easy to perform, can be repeated and does not leave any scars. It should be tied first.
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