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Human REXO4 is Required for Cell Cycle Progression.
bioRxiv
January 2025
Department of Chemistry and Biochemistry, University of California, Los Angeles, CA 90095, USA.
Human REXO4 is a poorly characterized exonuclease that is overexpressed in human cancers. To better understand the function of REXO4 and its relationship to cellular proliferation, we have undertaken multidisciplinary approaches to characterize its cell cycle phase-dependent subcellular localization and the cis determinants required for this localization, its importance to cell cycle progression and cell viability, its protein-protein association network, and its activity. We show that the localization of REXO4 to the nucleolus in interphase depends on an N-terminal nucleolar localization sequence and that its localization to the perichromosomal layer of mitotic chromosomes is dependent on Ki67.
View Article and Find Full Text PDFSequestration of ribosomal subunits as inactive 80S by targeting eIF6 limits mitotic exit and cancer progression.
Nucleic Acids Res
December 2024
Department of Biology, Saint Louis University, 3507 Laclede Ave, Saint Louis, MO 63103, USA.
Moderating the pool of active ribosomal subunits is critical for maintaining global translation rates. A factor crucial for modulating the 60S ribosomal subunit is eukaryotic translation initiation factor-6 (eIF6). Release of eIF6 from the 60S subunit is essential to permit 60S interactions with the 40S subunit.
View Article and Find Full Text PDFA role for the kinetochore protein, NUF2, in ribosome biogenesis.
Mol Biol Cell
February 2025
Department of Genetics, Yale University and the Yale School of Medicine, New Haven, 06520 CT.
Ribosome biogenesis (RB) is an intricate and evolutionarily conserved process that takes place mainly in the nucleolus and is required for eukaryotic cells to maintain homeostasis, grow in size, and divide. Our laboratory has identified the NUF2 protein, part of the mitotic kinetochore, in a genome-wide siRNA screen for proteins required for making ribosomes in MCF10A human breast epithelial cells. After rigorous validation and using several biochemical and cell-based assays, we find a role for NUF2 in pre-rRNA transcription, the primary and rate-limiting step of RB.
View Article and Find Full Text PDFDynamic Mitotic Localization of the Centrosomal Kinases CDK1, Plk, AurK, and Nek2 in .
Cells
September 2024
Department of Cell Biology, University of Potsdam, Karl-Liebknecht-Str. 24-25, 14476 Potsdam-Golm, Germany.
The centrosome of the amoebozoan model provides the best-established model for an acentriolar centrosome outside the . exhibits an unusual centrosome cycle, in which duplication is initiated only at the G2/M transition and occurs entirely during the M phase. Little is known about the role of conserved centrosomal kinases in this process.
View Article and Find Full Text PDFBioinformatics Analysis Screening and Identification of Key Biomarkers and Drug Targets in Human Glioblastoma.
Curr Med Chem
September 2024
Pirogov Russian National Research Medical University of the Ministry of Healthcare of Russian Federation, Moscow, Russian Federation.
Background: Glioblastoma is the most common type of brain cancer, with a prognosis that is unfortunately poor. Despite considerable progress in the field, the intricate molecular basis of this cancer remains elusive.
Aim: The aim of this study was to identify genetic indicators of glioblastoma and reveal the processes behind its development.
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