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Case report of neurobrucellosis: a rare complication and neuroimaging findings of a common disease.
Front Immunol
January 2025
Department of Neurology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background And Objective: Neurobrucellosis is a rare neurological disorder characterized by diverse clinical manifestations. Although several relevant cases were reported, our understanding of this disorder is limited. In this study, we presented the clinical and imaging characteristics of four cases of neurobrucellosis.
View Article and Find Full Text PDFLinezolid Dosing and Pharmacokinetics in North American Patients with Tuberculosis.
Clin Infect Dis
January 2025
Division of Infectious Diseases, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN, USA.
Introduction: Linezolid is recommended in treatment regimens for rifampin- or multi-drug-resistant tuberculosis. However, considerable pharmacokinetic variability exists, and long-term use is limited by adverse effects. This study evaluates the pharmacokinetics of linezolid in patients with tuberculosis from an international therapeutic drug monitoring service.
View Article and Find Full Text PDFA novel non-invasive murine model for rapidly testing drug activity via inhalation administration against .
Front Pharmacol
January 2025
State Key Laboratory of Respiratory Disease, Joint School of Life Sciences, Guangzhou Chest Hospital, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Medical University, Guangzhou, China.
The efficacy of many compounds against is often limited when administered via conventional oral or injection routes due to suboptimal pharmacokinetic characteristics. Inhalation-based delivery methods have been investigated to achieve high local therapeutic doses in the lungs. However, previous models, typically employing wild-type strains, were intricate, time-consuming, labor-intensive, and with poor reproducibility.
View Article and Find Full Text PDFDosing and route of administration of clindamycin given in combination with rifampicin.
Clin Microbiol Infect
January 2025
Université Paris Cité and Université Sorbonne Paris Nord, Inserm, IAME, F-75018 Paris, France; Unité Fonctionelle de Pharmacologie, GHU Paris Seine Saint-Denis, Assistance Publique-Hôpitaux de Paris (APHP), Université Sorbonne Paris Nord, Bondy, France.
Objectives: The aim of the present study was to develop a PK interaction model of intravenous (IV) and oral clindamycin when combined with rifampicin, and to determine whether appropriate clindamycin concentrations could be achieved for different doses and administration routes (oral, intermittent and continuous infusion) of clindamycin.
Methods: Five hundred and eighteen plasma samples were prospectively obtained from 124 patients treated for bone and joint infections. Population PK analysis was performed using Monolix software.
First Report of Causing Root Rot on Tulip Poplar in Tennessee and the United States.
Plant Dis
January 2025
Tennessee State University, Otis Floyd Nursery Research Center, 472 Cadillac Lane, McMinnville, Tennessee, United States, 37110;
Tulip poplar () is a member of the Magnolia family, is a large, fast-growing, long-lived, deciduous tree native to eastern North America. One-year-old tulip poplar seedlings grown under field conditions in a commercial nursery in Warren County, Tennessee, exhibited severe root rot in May 2024. Dark brown to black lesions were observed on the affected roots.
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