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Effect of testosterone treatment during puberty in boys with Klinefelter syndrome (The TIPY Study): protocol for a nationwide randomised, double-blinded, placebo-controlled study.
BMJ Open
March 2025
Department of Growth and Reproduction, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark
Introduction: Klinefelter syndrome (KS) is a genetic condition characterised by the presence of an extra X chromosome in males (47,XXY). KS is associated with various phenotypic characteristics in adult life, including infertility, hypogonadism and increased risk of type II diabetes, cardiovascular disease and osteoporosis. Additionally, individuals with KS often experience mental health challenges and functional impairments that significantly impact their quality of life.
View Article and Find Full Text PDFStructural characterizations and bioactivities of fucoidans from Dyctyopteris membranaceae and Padina pavonica with in silico investigations.
Int J Biol Macromol
March 2025
Laboratory of Pharmaceutical, Chemical and Pharmacological Drug Development LR12ES09, Faculty of Pharmacy, Université de Monastir, Monastir, Tunisia.
Fucoidans, a complex water-soluble sulfated polysaccharide is regarded as a valuable source of new drug development. The aim of this study was to characterize the chemical properties of fucoidans isolated from two brown algae Dyctyopteris membranaceae and Padina pavonica and to evaluate their anti-inflammatory, gastroprotective, antioxidant and immunomodulatory activities. The characterization of fucoidans was investigated with colorimetric techniques and Fourier transform infrared spectroscopy.
View Article and Find Full Text PDFProstaglandin E2 alleviates inflammatory response and lung injury through EP4/cAMP/IKK/NF-κB pathway.
Biochim Biophys Acta Mol Basis Dis
March 2025
Affiliated Yueqing Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325600, China. Electronic address:
Purpose: Prostaglandin E2 (PGE2), a pivotal lipid metabolite, plays a dual role in inflammation, manifesting both pro-inflammatory and anti-inflammatory effects, which are significantly influenced by the cellular microenvironment and receptor subtype. Although recent studies have highlighted the anti-inflammatory potential of PGE2, its role in toll-like receptor (TLR)-associated inflammation and the underlying mechanisms have not fully elucidated. Consequently, the primary aim of this study was to assess the anti-inflammatory efficacy of PGE2 in TLR-related inflammation and to elucidate the associated mechanisms.
View Article and Find Full Text PDFIn Vitro Inhibition of Voltage-Dependent Sodium Currents by the Antifungal Drug Amorolfine.
J Biol Chem
March 2025
Department of Neurology, Yale School of Medicine, New Haven, CT, USA; Center for Neuroscience & Regeneration Research, Yale University, West Haven, CT, USA; Neuro-Rehabilitation Research Center, Veterans Affairs Connecticut Healthcare System, West Haven, CT, USA. Electronic address:
Voltage-gated sodium (Nav) channels are critical for electrical signaling, and their pharmacological modulation can be leveraged for the development of therapeutic agents targeting various disorders. The local anesthetic (LA) site on Nav channels is particularly important, as it is a common target for many clinically used inhibitors, including anticonvulsants and antiarrhythmics. Our goal was to identify novel Nav channel inhibitors by leveraging physicochemical criteria, focusing on potential LA site binding candidates.
View Article and Find Full Text PDFEnhancing throughput and robustness of the fibroblast to myofibroblast transition assay.
SLAS Discov
March 2025
Discovery Sciences, R&D, AstraZeneca, Gothenburg, Sweden. Electronic address:
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive age-related lung disease with an average survival of 3-5 years post-diagnosis if left untreated. It is characterized by lung fibrosis, inflammation, and destruction of lung architecture, leading to worsening respiratory symptoms and physiological impairment, ultimately culminating in progressive respiratory failure. The development of novel therapeutics for the treatment of IPF represents a significant unmet medical need.
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