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The HR antagonist, JNJ-7777120 treatments ameliorate mild traumatic brain injury by reducing oxidative damage, inflammatory and apoptotic responses through blockage of the ERK1/2/NF-κB pathway in a rat model.
Exp Neurol
December 2024
Department of Molecular Biology and Genetics, Faculty of Science, Istanbul University, Istanbul, Turkiye. Electronic address:
Growing evidence reveals that microglia activation and neuroinflammatory responses trigger cell loss in the brain. Histamine is a critical neurotransmitter and promotes inflammatory responses; thus, the histaminergic system is a potential target for treating neurodegenerative processes. JNJ-7777120, a histamine H4 receptor (HR) antagonist, has been shown to alleviate inflammation, brain damage, and behavioral deficits effectively, but there is no report on its role in brain trauma.
View Article and Find Full Text PDFValidation of the Histamine- and Heat-Induced Axon-Reflex Flare Response in a Nonselected Population of People With Type 1 Diabetes.
Muscle Nerve
February 2025
Steno Diabetes Center North Denmark, Aalborg University Hospital, Aalborg, Denmark.
Introduction/aims: Diabetic peripheral neuropathy affects small nerve fibers early, but adequate evaluation has proven difficult. One method for functional assessment of small nerve fiber function is the axon-reflex flare (ARF) response. This study aimed to 1) validate the histamine-induced ARF response in a nonselected population with diabetes, 2) compare the response to that induced by local heating, and 3) compare both methods to an established method (quantitative sensory testing) in a nonselected population with diabetes.
View Article and Find Full Text PDFGastroesophageal reflux disease in chronic obstructive pulmonary disease.
Respir Investig
September 2024
Department of Respiratory Medicine, Nara Medical University, 840 Shijo-cho, Kashihara, Nara, 634-8522, Japan.
Article Synopsis
- * Patients with both GERD and COPD often experience worsened quality of life and a higher risk of respiratory exacerbations, making it essential to diagnose and manage GERD effectively through questionnaires, endoscopies, and other clinical methods.
- * Treatment options for GERD include acid-reducing medications and, for those who don't respond, surgical options like endoscopic fundoplication; early evaluation for GERD is especially important in COPD patients due to their increased cancer risk.
The GABAergic pathway from anterior cingulate cortex to lateral hypothalamus area regulates irritable bowel syndrome in mice and its underlying mechanism.
J Neurochem
September 2024
Department of Pathophysiology, School of Basic Medicine, Qingdao University, Qingdao, China.
Irritable bowel syndrome (IBS), which is characterized by chronic abdominal pain, has a high global prevalence. The anterior cingulate cortex (ACC), which is a pivotal region involved in pain processing, should be further investigated regarding its role in the regulation of visceral sensitivity and mental disorders. A C57BL/6J mouse model for IBS was established using chronic acute combining stress (CACS).
View Article and Find Full Text PDFCerebral Anoxia in an 18-year-old Patient Being Treated for Major Depressive Disorder: How Forensic Detective Work Uses Medical Knowledge Including Clinical Pharmacology to Solve Cases.
J Psychiatr Pract
May 2024
Department of Psychiatry and Behavioral Sciences, University of Kansas School of Medicine-Wichita, Wichita, KS.
This column is the first of a 3-part series illustrating the importance of medical knowledge, including clinical pharmacology, in a forensic context. This first case involved an 18-year-old high school student who suffered an anoxic brain injury and remained in a state of permanent decorticate posture, unresponsive except for grunts and primitive movements until he died several years later. Our investigation began by ruling out plausible causes that were suggested by the defense in the malpractice suit.
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