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Human Autoantigen Atlas: Searching for the Hallmarks of Autoantigens.
J Proteome Res
June 2023
State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences-Beijing (PHOENIX Center), Beijing Institute of Lifeomics, Beijing 102206, China.
Article Synopsis
- Understanding autoimmunity to the body's own proteins is key for diagnosing and treating autoimmune diseases, prompting the development of the AAgAtlas portal which lists over 8,000 autoantigens linked to various human diseases.
- The portal allows users to explore the properties and characteristics of these autoantigens, highlighting their evolutionary conservation and common features like hydrophilic amino acids that are often found on protein surfaces.
- Findings indicate that the production of antibodies targeting these autoantigens is related to genetic variations and abnormal protein expression in diseases, aiding in the identification of potential biomarkers for autoimmune conditions.
Hashimoto's thyroiditis: An update on pathogenic mechanisms, diagnostic protocols, therapeutic strategies, and potential malignant transformation.
Autoimmun Rev
October 2020
Department of Sense Organs, Sapienza University of Rome, Italy. Electronic address:
Hashimoto's thyroiditis, characterized by thyroid-specific autoantibodies, is one of the commonest autoimmune disorders. Although the exact etiology has not been fully elucidated, Hashimoto's thyroiditis is related to an interaction among genetic elements, environmental factors and epigenetic influences. Cellular and humoral immunity play a key role in the development of the disease; thus, a T and B cells inflammatory infiltration is frequently found.
View Article and Find Full Text PDFHypercalcemia of Malignancy in a Dog Diagnosed With Cholangiocellular Carcinoma.
Top Companion Anim Med
June 2019
Departament de Medicina i Cirurgia Animals, Facultat de Veterinària, Universitat Autònoma de Barcelona, Bellaterra, Spain. Electronic address:
A 4-year-old, neutered male Golden Retriever was presented with a 1-week history of weight loss, polyuria, and polydipsia. The diagnostic workup showed an increased ionized calcium concentration, mild increase in serum creatinine and urea concentration, and severe hyperlipasemia. A complete abdominal ultrasound revealed multiple hepatic nodules.
View Article and Find Full Text PDFA case of hypercalcemia in a heifer presumably due to mammary carcinoma bovine hypercalcemia of malignancy.
Vet Clin Pathol
June 2019
Department of Comparative Pathobiology, Purdue University College of Veterinary Medicine, West Lafayette, Indiana.
Mammary carcinoma is rare in cattle with only a handful of cases found in the literature, and none have reported an associated hypercalcemia. An 8-year-old Holstein-Friesian heifer was presented to the Purdue University Veterinary Teaching Hospital's Large Animal Hospital with a 3-month history of lethargy. Laboratory abnormalities included ionized hypercalcemia and hypophosphatemia (2.
View Article and Find Full Text PDFLung Recurrence of Papillary Thyroid Cancer Diagnosed With Antithyroglobulin Antibodies After 10 Years From Initial Treatment.
Front Endocrinol (Lausanne)
October 2018
Unit of Endocrinology, Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.
Papillary thyroid cancer (PTC) is the most common endocrine malignancy. More than 98% of patients achieve an excellent response with no evidence of clinical, biochemical, or structural disease after initial treatment. In these patients structural recurrence is rare, more frequently diagnosed in the first 5 years from initial treatment and almost invariably localized in neck lymph nodes.
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