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Computational Simulation Study-Based Formulation Development and Characterization of MethylprednisoloneLoaded Nanoparticles Containing Chitosan and Pectin to Treat Nocturnal Asthma.
Polymers (Basel)
December 2024
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia.
Nocturnal asthma (NA) is a high-prevalence disease that causes severe respiratory issues, leading to death from early midnight to early morning. In this research, nanoparticulate drug delivery system of methylprednisolone (MP) was developed using chitosan (CH) and pectin (PEC). MP is a synthetic corticosteroid medication widely used for its potent anti-inflammatory activity.
View Article and Find Full Text PDFOral colon-targeted responsive chitosan/pectin-based nanoparticles propels the application of tofacitinib in colitis therapy.
Sci Rep
January 2025
School of Basic Medicine, Qingdao Medical College, Qingdao University, Qingdao, China.
Tofacitinib (Tof), a commercially available pan-Janus kinases inhibitor, is approved for the treatment of moderate to severe ulcerative colitis. However, its clinical application is limited due to dose-dependent systemic side effects. The present study aims to develop an efficient oral colon-targeted drug delivery systems using prebiotic pectin (Pcn) and chitosan (Csn) polysaccharides as a shell, with Tof loaded into a Bovine Serum Albumin (BSA) core, and improving it with chondroitin sulfate (Chs), thus constructing Tof@BSA-Chs-CP nanoparticles (NPs).
View Article and Find Full Text PDFAdvances in bio-polymer coatings for probiotic microencapsulation: chitosan and beyond for enhanced stability and controlled release.
Des Monomers Polym
December 2024
Operational Research Centre in Healthcare, Near East University, Nicosia, Cyprus.
This review paper analyzes recent advancements in bio-polymer coatings for probiotic microencapsulation, with a particular emphasis on chitosan and its synergistic combinations with other materials. Probiotic microencapsulation is essential for protecting probiotics from environmental stresses, enhancing their stability, and ensuring effective delivery to the gut. The review begins with an overview of probiotic microencapsulation, highlighting its significance in safeguarding probiotics through processing, storage, and gastrointestinal transit.
View Article and Find Full Text PDFStructural Characterization of Water-Soluble Pectin from the Fruit of and Its Protective Effects against DSS-Induced Colitis in Mice.
J Agric Food Chem
January 2025
Institute of Agro-Products Processing Science and Technology, Sichuan Academy of Agricultural Sciences, Chengdu 610066 Sichuan, China.
Polysaccharides from L. were investigated for their structural characterization and anti-inflammatory activity. Four low polymer dispersity index (PDI) subfractions were obtained: DRP-1 (153.
View Article and Find Full Text PDFDevelopment of plantaricin RX-8 loaded pectin/4-carboxyphenylboric acid/carboxymethyl chitosan hydrogel microbead: A potential targeted oral delivery system.
Int J Biol Macromol
December 2024
School of Food and Health, Beijing Technology and Business University, Beijing 100048, China; Key Laboratory of Geriatric Nutrition and Health, Ministry of Education, Beijing Technology and Business University, Beijing 100048, China; Beijing Engineering and Technology Research Center of Food Additives, Beijing Technology and Business University, Beijing 100048, China. Electronic address:
Bacteriocin can effectively improve the gut inflammation for their superior antibacterial activity. However, its inherent attributes, such as easily degraded and off-target effect in the gastrointestinal environment, make bacteriocins' efficient oral delivery a great challenge. Herein, a pectin/4-carboxyphenylboric acid/carboxymethyl chitosan (PEC/CPBA/CMCS) hydrogel microbead targeted oral delivery system was innovatively developed for the plantaricin RX-8 protective delivery, precisely targeted inflammatory microenvironment (IME) and sustained released plantaricin RX-8 by pH/ROS dual stimulation response.
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