Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1259/0007-1285-42-497-391 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Maternal Minocycline as Fetal Therapy in a Rat Model of Myelomeningocele.
J Surg Res
September 2024
Division of General Pediatric Surgery, Department of Surgery, Johns Hopkins School of Medicine, Baltimore, Maryland. Electronic address:
Article Synopsis
- This study explored the effects of the antibiotic minocycline on reducing inflammation and cell death in fetal rats with myelomeningocele (MMC) when administered to pregnant rats.
- Pregnant rats were treated with different substances to induce MMC in their fetuses, and then some mothers received minocycline, with their offspring's spinal cords analyzed for inflammation and cell death markers.
- The results suggested that minocycline exposure led to lower levels of inflammation and cell death markers in the fetal spinal cords, indicating its potential as a prenatal treatment for spinal cord issues associated with MMC.
Antibiotic use in endodontic treatment during pregnancy: A narrative review.
Eur J Transl Myol
October 2022
Department of Endodontics, Faculty of Dentistry, Zahedan University of Medical Sciences, Zahedan.
More than half of pregnant women are usually affected by odontogenic pain affects. Pain often accompanies periapical or pulp infections and increases the risks to pregnant patients and their fetuses. The American Dental Association, in partnership with the American College of Obstetricians and Gynecologists, has offered a strong declaration reaffirming the significance of suitable and timely oral health care as an indispensable constituent of a healthy pregnancy.
View Article and Find Full Text PDFA CCR5 antagonist, maraviroc, alleviates neural circuit dysfunction and behavioral disorders induced by prenatal valproate exposure.
J Neuroinflammation
July 2022
Institute of Neuroscience, Tokushima Bunri University, Kagawa, 769-2193, Japan.
Background: Valproic acid (VPA) is a clinically used antiepileptic drug, but it is associated with a significant risk of a low verbal intelligence quotient (IQ) score, attention-deficit hyperactivity disorder and autism spectrum disorder in children when it is administered during pregnancy. Prenatal VPA exposure has been reported to affect neurogenesis and neuronal migration and differentiation. In addition, growing evidence has shown that microglia and brain immune cells are activated by VPA treatment.
View Article and Find Full Text PDFMaternal Acetate Supplementation Reverses Blood Pressure Increase in Male Offspring Induced by Exposure to Minocycline during Pregnancy and Lactation.
Int J Mol Sci
July 2022
Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung 833, Taiwan.
Article Synopsis
- * In a study with pregnant rats, maternal supplementation with acetate was found to protect offspring from hypertension caused by the antibiotic minocycline, while also maintaining levels of acetic acid in the blood.
- * The findings suggest that modifying gut microbial metabolites, like short-chain fatty acids, may offer new strategies for preventing hypertension early on, addressing a significant global health issue.
Tetracyclines and bone: Unclear actions with potentially lasting effects.
Bone
June 2022
Department of Oral Health Sciences, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Stomatology-Division of Periodontics, College of Dental Medicine, Medical University of South Carolina, Charleston, SC 29425, USA; Department of Pediatrics-Division of Endocrinology, College of Medicine, Medical University of South Carolina, Charleston, SC 29425, USA. Electronic address:
Tetracyclines are a broad-spectrum class of antibiotics that have unclear actions with potentially lasting effects on bone metabolism. Initially isolated from Streptomyces, tetracycline proved to be an effective treatment for Gram +/- infections. The emergence of resistant bacterial strains commanded the development of later generation agents, including minocycline, doxycycline, tigecycline, sarecycline, omadacycline, and eravacycline.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!