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Impact of introducing transnasal endoscopy on expanding diagnostic endoscopy services.
BMJ Open Qual
January 2025
Department of Gastroenterology, University Hospital Llandough, Llandough, South Glamorgan, UK
Introduction: Demand for endoscopic services is outstripping capacity in the UK. Transnasal endoscopy (TNE) utilises a narrow calibre endoscope to pass through the nasal passages, thereby reducing retching and discomfort. It is better tolerated compared with standard transoral endoscopy (TOE) but is still rarely used as a diagnostic modality.
View Article and Find Full Text PDFImage-guided Interventions for Core Muscle Injury and Other Disorders in the Pubic Symphysis.
Radiographics
February 2025
Department of Medical Imaging, The Ottawa Hospital, 501 Smyth Rd, Ottawa, ON, Canada K1H 8L6 (D.V.F., J.L.); Department of Radiology, Radiation Oncology and Medical Physics, Faculty of Medicine, University of Ottawa, Ottawa, Ontario, Canada (D.V.F., J.L.); Ottawa Hospital Research Institute, Ottawa, Ontario, Canada (D.V.F., J.L.); and Department of Radiology, St. Paul's Hospital, University of British Columbia, Vancouver, British Columbia, Canada (T.M.).
Formerly termed or , core muscle injury (CMI) encompasses abnormality of structures within the so-called core, which is essentially the hip, abdomen, and pubis. Compared with data on image-guided procedures of other joints, information regarding procedures performed to address CMI and other disorders of the pubic symphysis is lacking. These procedures can be daunting given the joint's small size, surrounding critical neurovascular structures, and three-dimensional anatomy.
View Article and Find Full Text PDFEvaluating plasma biomarkers NfL, GFAP, GDF15, and FGF21 as indicators of disease severity in Charcot-Marie Tooth patients.
Front Neurol
January 2025
14th European Reference Network in Neuromuscular Disorders (EURO-NMD), Scientific Laboratory of Molecular Genetics, Riga Stradins University, Riga, Latvia.
Background: Charcot-Marie-Tooth disease (CMT), a slowly advancing hereditary nerve disorder, presents a significant challenge in the medical field. Effective drugs for treatment are lacking, and we struggle to find sensitive markers to track the disease's severity and progression. In this study, our objective was to investigate the levels of neurofilament light chain (NfL), glial fibrillary acid protein (GFAP), fibroblast growth factor 21 (FGF-21) and growth differentiation factor 15 (GDF-15) in individuals with CMT and to compare them to a control group.
View Article and Find Full Text PDFThe Role of CBGTC Synaptic Neurotransmission in the Pathophysiology of Tics.
Psychiatr Clin North Am
March 2025
Department of Neurology, Johns Hopkins University School of Medicine, Kennedy Krieger Institute, Baltimore, MD, USA.
The pathophysiology of tic disorders involves an alteration in the transmission of messages through the cortico-basal ganglia-thalamo-cortical circuit. A major requirement for the passage of a message through this circuit is an intact chemically mediated synaptic neurotransmitter system (ie, neurotransmitters and second messengers). This article reviews the scientific evidence supporting the involvement of a variety of neurotransmitters (ie, dopamine, glutamate, gamma-aminobutyric acid, serotonin, acetylcholine, and the opioid system).
View Article and Find Full Text PDFFrom primordial inscription to word representation.
Int J Psychoanal
December 2024
Brazilian Psychoanalytic Society of Rio de Janeiro, Rio de Janeiro, Brazil.
This work seeks to examine two aspects of the passage from the somato-sensory function to the psyche, in an attempt to explore in greater detail the construction of mental representations. The first aspect is the primordial inscription, which ends in the formation of a pictogram. This is an attempt to represent the "thing".
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