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Danio rerio, commonly known as zebrafish, is an established model organism for the developmental and cell biology studies. Although significant progress has been made in the analysis of the D. rerio genome, cytogenetic studies face challenges due to the unclear identification of chromosomes.

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Synthetic intergeneric amphydiploids and genome-substituted wheat forms are an important source for transferring agronomically valuable genes from wild species into the common wheat (Triticum aestivum L.) genome. They can be used both in academic research and for breeding purposes as an original material for developing wheat-alien addition and substitution lines followed by translocation induction with the aid of irradiation or nonhomologous chromosome pairing.

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Article Synopsis
  • Thyroid and salivary gland cytopathology often present diagnostic challenges due to overlapping features and rare conditions, prompting a focused seminar at the 45th European Congress of Cytology to address these issues.
  • The seminar showcased complex cases using fine-needle aspiration cytology (FNAC) alongside histopathological and molecular analyses to differentiate between benign and malignant lesions.
  • The findings emphasize the necessity of a comprehensive, multidisciplinary diagnostic approach that integrates cytological, clinical, and histopathological data for accurate patient management.
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Secondary haematological dysplasia after CAR-T-cell therapy for acute lymphoblastic leukaemia in children.

Br J Haematol

January 2025

Leukemia and Lymphoma Department, CAR-T-Cell Unit, Pediatric Cancer Center Barcelona (PCCB), Hospital Sant Joan de Déu de Barcelona, University of Barcelona, Esplugues de Llobregat, Spain.

The use of CAR-T is becoming more widespread in the treatment of haematological malignancies. In adults, secondary myelodysplastic syndromes (MDS) after CAR-T have been described. However, there are currently no data on the risk of MDS following CAR-T in children treated for acute lymphoblastic leukaemia (ALL).

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Assessment of cytogenetic homeostasis of indicator animals is of great importance in ecological monitoring. The simplest method of its study is micronucleus analysis. Animals with nuclear erythrocytes are often used as indicator animals.

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