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Utilization of a human Liver Tissue Chip for drug-metabolizing enzyme induction studies of perpetrator and victim drugs.
Drug Metab Dispos
January 2025
Javelin Biotech, Inc, Woburn, Massachusetts. Electronic address:
Polypharmacy-related drug-drug interactions (DDIs) are a significant and growing healthcare concern. An increasing number of therapeutic drugs on the market underscores the necessity to accurately assess new drug combinations during preclinical evaluation for DDIs. In vitro primary human hepatocytes (PHH) models are only applicable for short-term induction studies because of their rapid loss of metabolic function.
View Article and Find Full Text PDFFrom Structure to Function: Isatin Derivatives as a Promising Class of Antiviral Agents.
Curr Drug Targets
January 2025
School of Pharmaceutical Sciences, Shoolini University, Solan, HP, India.
A range of heterocyclic compounds, including Isatin (oneH-indole-2, 3-dione) and its by-products, have been shown to represent potential unit blocks in the synthesis of potential medicinal agents. Numerous studies have been carried out on isatin, its synthesis, biological uses, and its chemical composition since when it was discovered. Functionally, these isatin-containing heterocycles have demonstrated antibacterial, antidiabetic, antiviral, antitubercular, and anticancer properties, among many others.
View Article and Find Full Text PDFBackground Tuberculosis (TB) remains a major cause of global morbidity and mortality. Efforts to control TB are hampered by the lengthy and cumbersome treatment required to eradicate the infection. Bacterial persistence during exposure to bactericidal antibiotics is at least partially mediated by the bacterial stringent response enzyme, Rel .
View Article and Find Full Text PDFNovel Quinoline Schiff-Bases as Mtb DNA Gyrase Inhibitors - A Combined In Vitro and In Silico Study.
Chem Biodivers
January 2025
University of KwaZulu-Natal College of Agriculture Engineering and Science, Department of Chemistry, Westville Campus, Durban, SOUTH AFRICA.
A new series of quinoline Schiff-bases was designed, synthesized, and characterized using 1H NMR, 13C NMR, and HRMS analysis. Further, all the compounds were screened for their antitubercular, antibacterial, and antifungal activity, and the minimum inhibitory concentrations (MICs) were determined. Among all, compound 7f displayed a significantly potent broad-spectrum antitubercular and antimicrobial activity against most of the tested strains of bacteria and fungi, with MIC values in the range of 1.
View Article and Find Full Text PDFEndovascular management of an aortic injury in thoracic kyphosis surgery: a minimally invasive rescue for a life-threatening injury.
BMJ Case Rep
January 2025
Department of Orthopaedics and Spine Surgery, Military Hospital Khadki, Pune, Maharashtra, India.
A patient in his early adolescence, who was treated for T5-T6 tubercular spondylodiscitis with an un-instrumented decompression, presented at 36 months post-index surgery, for post-laminectomy instability and kyphosis, after completing his requisite antitubercular treatment. He underwent thoracic posterior instrumented kyphosis correction and anterior reconstruction, with a T5-T6 partial corpectomy and corpectomy spacer placement, through a posterior midline incision. On the second postoperative day, he started complaining of pain on the left side of his chest, abdomen and left shoulder.
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