Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
In (Mtb), persisters are genotypically drug-sensitive bacteria that nonetheless survive antibiotic treatment. Persisters represent a significant challenge to shortening TB treatment and preventing relapse, underscoring the need for new therapeutic strategies. In this study, we screened 2,336 FDA-approved compounds to identify agents that enhance the sterilizing activity of standard anti-TB drugs and prevent the regrowth of persisters.
View Article and Find Full Text PDFTreatment and Toxicity Considerations in Tuberculosis: A Narrative Review.
Cureus
June 2024
Department of Pain Medicine, Paolo Procacci Foundation, Rome, ITA.
Article Synopsis
- * Treatment typically involves a combination of four medications, each targeting different aspects of the bacteria, but they all come with significant and sometimes debilitating side effects.
- * The side effects, including neuropathy from isoniazid and optic neuropathy from ethambutol, may lead to higher rates of noncompliance with treatment, indicating a need for better management strategies.
Confronting Tuberculosis: A Synthetic Quinoline-Isonicotinic Acid Hydrazide Hybrid Compound as a Potent Lead Molecule Against .
ACS Infect Dis
June 2024
Laboratory of Molecular Pathogenesis, Department of Biochemistry, School of Life Sciences, University of Hyderabad (UoH), Hyderabad 500046, India.
The current tuberculosis (TB) treatment is challenged by a complex first-line treatment for drug-sensitive (DS) TB. Additionally, the prevalence of multidrug (MDR)- and extensively drug (XDR)-resistant TB necessitates the search for new drug prototypes. We synthesized and screened 30 hybrid compounds containing aminopyridine and 2-chloro-3-formyl quinoline to arrive at a compound with potent antimycobacterial activity, UH-NIP-16.
View Article and Find Full Text PDFTc-Ethambutol Scan with SPECT/CT in Knee Joint Tuberculosis.
Indian J Nucl Med
November 2022
Department of Orthopedics, All India Institute of Medical Sciences, New Delhi, India.
Modalities for imaging of are limited and inadequately studied. One such modality is Tc-ethambutol scintigraphy which has shown promising results for diagnosis of tuberculosis (TB). Ethambutol, one of the primary antitubercular drugs, is bacteriostatic which acts on the mycolic acid cell wall synthesis of the .
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!