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Milk Fat Globules: 2024 Updates.
Newborn (Clarksville)
March 2024
Global Newborn Society, Clarksville Maryland, United States of America.
Article Synopsis
- * MFGs feature a unique structure with a lipid core and a membrane rich in bioactive components that aid in energy release and support immune health in developing gastrointestinal tracts.
- * Research suggests MFGs can be enhanced to address specific nutritional deficiencies while also having potential therapeutic benefits for neurodevelopment and defense against infections.
Severe Spinal Cord Injury in Rats Induces Chronic Changes in the Spinal Cord and Cerebral Cortex Metabolism, Adjusted by Thiamine That Improves Locomotor Performance.
Front Mol Neurosci
March 2021
Faculty of Bioengineering and Bioinformatics, Lomonosov Moscow State University, Moscow, Russia.
Article Synopsis
- The study focuses on developing strategies to reduce long-term brain changes resulting from severe spinal cord injury (SCI) by analyzing metabolic shifts in rats after injury.
- It was found that the mitochondrial 2-oxoglutarate dehydrogenase complex (OGDHC) was significantly downregulated in both the spinal cord (90%) and cerebral cortex (30%), leading to chronic metabolic alterations.
- Treatment with thiamine (vitamin B1) post-SCI showed positive effects on brain metabolism and locomotor recovery, while another substance, TEGP, exacerbated metabolic issues, indicating the importance of OGDHC regulation in SCI outcomes.
The dual reno- and neuro-protective effects of dimethyl fumarate against uremic encephalopathy in a renal ischemia/reperfusion model.
Pharmacol Rep
August 2020
Department of Pharmacology and Toxicology, Faculty Pharmacy, Cairo University, Kasr El-Aini Str, Cairo, 11562, Egypt.
Background: Dimethyl fumarate (DMF), a Nrf2 activator approved for multiple sclerosis (MS) in 2013, showed promising antioxidant and anti-inflammatory effects against cerebral injury. However, its mechanistic maneuver in renal ischemia/reperfusion (I/R) injury and its associated uremic encephalopathy has not been previously highlighted.
Methods: To fulfill this aim, rats were divided into 4 groups; sham-operated, renal I/R, and 14 days pretreated DMF (15 and 25 mg/kg/day, orally).
Venomics of the asp viper Vipera aspis aspis from France.
J Proteomics
April 2020
Institut des Biomolécules Max Mousseron, UMR 5247, Univ Montpellier, CNRS, Place Eugène Bataillon, 34095 Montpellier CEDEX 5, France. Electronic address:
The asp viper Vipera aspis aspis is a venomous snake found in France, and despite its medical importance, the complete toxin repertoire produced is unknown. Here, we used a venomics approach to decipher the composition of its venom. Transcriptomic analysis revealed 80 venom-annotated sequences grouped into 16 gene families.
View Article and Find Full Text PDFELISA based on a recombinant Paragonimus heterotremus protein for serodiagnosis of human paragonimiasis in Thailand.
Parasit Vectors
May 2018
Department of Helminthology, Faculty of Tropical Medicine, Mahidol University, Bangkok, 10400, Thailand.
Background: Paragonimus heterotremus is the main causative agent of paragonimiasis in Thailand. In Western blot diagnostic assays for paragonimiasis, the 35 kDa band present in crude P. heterotremus somatic extracts represents one of the known diagnostic bands.
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