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Characterization of a primary cellular airway model for inhalative drug delivery in comparison with the established permanent cell lines CaLu3 and RPMI 2650.
In Vitro Model
December 2024
Institute of Applied Biotechnology, University of Applied Science Biberach, Hubertus-Liebrecht Strasse 35, 88400 Biberach, Germany.
Purpose: For optimization of respiratory drug delivery, the selection of suitable in vitro cell models plays an important role in predicting the efficacy and safety of (bio)pharmaceutics and pharmaceutical formulations. Therefore, an in-depth comparison of different primary and permanent in vitro cellular airway models was performed with a focus on selecting a suitable model for inhalative antibodies.
Methods: Primary cells isolated from the porcine trachea were compared with the established human cell lines CaLu3 and RPMI 2650.
Interactive Coupling Relaxation of Dipoles and Wagner Charges in the Amorphous State of Polymers Induced by Thermal and Electrical Stimulations: A Dual-Phase Open Dissipative System Perspective.
Polymers (Basel)
January 2025
Rheology Department, Polymat Institute, University of the Basque Country, 20018 Donostia-San Sebastian, Euskadi, Spain.
This paper addresses the author's current understanding of the physics of interactions in polymers under a voltage field excitation. The effect of a voltage field coupled with temperature to induce space charges and dipolar activity in dielectric materials can be measured by very sensitive electrometers. The resulting characterization methods, thermally stimulated depolarization (TSD) and thermal-windowing deconvolution (TWD), provide a powerful way to study local and cooperative relaxations in the amorphous state of matter that are, arguably, essential to understanding the glass transition, molecular motions in the rubbery and molten states and even the processes leading to crystallization.
View Article and Find Full Text PDFFinite Element Analysis of Electromagnetic Characteristics of a Single-Phase Permanent Magnet Linear Oscillation Actuator.
Sensors (Basel)
January 2025
Department of Electrical Engineering, Southeast University, Nanjing 210096, China.
The electromagnetic characteristics of a single-phase permanent magnet linear oscillation actuator are analyzed by the finite element method. Firstly, the basic structure and operation principle of the linear oscillation actuator are introduced. The internal stator slot and arc tooth are used to reduce the detent force.
View Article and Find Full Text PDFA Versatile Dual-Responsive Shape-Memory Gripper via Additive Manufacturing Toward High-Performance Cross-Scale Objects Maneuvering.
Small
January 2025
Department of Materials Physics and New Energy Device School of Materials Science and Engineering, Hefei University of Technology, Hefei, 230009, China.
Smart grippers serving as soft robotics have garnered extensive attentions owing to their great potentials in medical, biomedical, and industrial fields. Though a diversity of grippers that account for manipulating the small objects (e.g.
View Article and Find Full Text PDFResults of ICE-Guided Isolation of the Superior Vena Cava With Pulsed Field Ablation.
JACC Clin Electrophysiol
January 2025
Texas Cardiac Arrhythmia Institute, St. David's Medical Center, Austin, Texas, USA; Interventional Electrophysiology, Scripps Clinic, San Diego, California, USA; Metro Health Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio, USA; Department of Biomedicine and Prevention, Division of Cardiology, University of Tor Vergata, Rome, Italy. Electronic address:
Background: Earlier studies have documented the risk for sinoatrial node injury and phrenic nerve paralysis as complications following radiofrequency catheter ablation for electrical isolation of the superior vena cava (SVCI).
Objectives: The aim of this study was to assess the safety and feasibility of SVCI in patients with atrial fibrillation undergoing pulsed field ablation (PFA) METHODS: Six hundred sixteen consecutive patients undergoing PFA for pulmonary vein isolation plus SVCI were included in this multicenter analysis. Superior vena cava (SVC) ablation was performed under the continuous guidance of intracardiac echocardiography.
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