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Optimization Study of a High-Efficiency Preservative for Ammonia-Free Concentrated Natural Rubber Latex.
Polymers (Basel)
January 2025
Hainan Natural Rubber Technology Innovation Center, Rubber Research Institute, Chinese Academy of Tropical Agricultural Sciences, Haikou 571101, China.
Ammonia is commonly used as a preservative in the production of concentrated natural rubber latex (CNRL) and latex products; however, it poses a serious risk to human health and the environment. In this study, we investigated a thioacetamide derivative (TD) as a preservative of ammonia-free CNRL and the optimization of a stabilization system comprising potassium hydroxide (KOH), lauric acid (LA), and sodium dodecyl sulfate (SDS) to enhance its preservation effect. The results revealed that an optimal amount of TD (0.
View Article and Find Full Text PDFInvestigating the Effect and Potential Mechanism of Rhamnetin 3--α-Rhamnoside on Acute Liver Injury In Vivo and In Vitro.
Pharmaceuticals (Basel)
January 2025
School of Pharmaceutical Sciences & Institute of Materia Medica, Shandong First Medical University & Shandong Academy of Medical Science, No. 6699 Qingdao Road, Jinan 250117, China.
: Rhamnetin 3--α-rhamnoside (ARR) is a major flavonoid of the herb Franch. & Sav., which has been used for treating liver diseases in China.
View Article and Find Full Text PDFBerberine Inhibits the Disruption of the Blood-Brain Barrier and Glial Cell Activation in a Rat Model of Acute Hepatic Encephalopathy.
Phytother Res
January 2025
Laboratory of Molecular NeuroTherapeutics, Department of Pharmacology and Toxicology, National Institute of Pharmaceutical Education and Research, Raebareli, Uttar Pradesh, India.
Background And Aim: Hepatic encephalopathy (HE) is a complex neurological disorder in individuals with liver diseases, necessitating effective neuroprotective interventions to alleviate its adverse outcomes. Berberine (BBR), a natural compound with well-established anti-fibrotic and neuroprotective properties, has not been extensively studied in the context of glial activation under hyperammonaemic conditions. This study evaluates the neuroprotective potential of BBR in a thioacetamide (TAA)-induced HE rat model, focusing on its effects on glial activation and NLRP3 inflammasome signalling.
View Article and Find Full Text PDFTherapeutic Potential of Hongjam in A Diethylnitrosamine and Thioacetamide-induced Hepatocellular Carcinoma Mouse Model.
J Cancer Prev
December 2024
College of Pharmacy and Institute of Pharmaceutical Sciences, CHA University, Seongnam, Korea.
Hepatocellular carcinoma (HCC) is the most common and lethal type of primary liver cancer, frequently arising from chronic liver injury and inflammation. Despite treatment advancements, HCC prognosis remains poor, emphasizing the need for effective preventive and therapeutic strategies. This study investigates the hepatoprotective and anti-tumor effects of Hongjam, a steamed freeze-dried silkworm powder, in a diethylnitrosamine (DEN) and thioacetamide (TAA)-induced HCC mouse model.
View Article and Find Full Text PDFA Small-Molecule Inhibitor of Gut Bacterial Urease Protects the Host from Liver Injury.
ACS Chem Biol
January 2025
Harvard University, Department of Chemistry and Chemical Biology, Cambridge, Massachusetts 02138, United States.
Hyperammonemia is characterized by the accumulation of ammonia within the bloodstream upon liver injury. Left untreated, hyperammonemia contributes to conditions such as hepatic encephalopathy that have high rates of patient morbidity and mortality. Previous studies have identified gut bacterial urease, an enzyme that converts urea into ammonia, as a major contributor to systemic ammonia levels.
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