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Generative AI in a new era of computer model-informed tobacco research: a short report.
Tob Control
January 2025
Department of Population and Public Health Sciences, University of Southern California, Los Angeles, California, USA.
Background: Social media influencers who promote e-cigarettes on Instagram or TikTok for tobacco brands use marketing tactics to increase the appeal of their promotional content, for example, depicting e-cigarettes alongside healthy lifestyle or entertainment imagery that could decrease youths' risk perceptions of e-cigarettes. Monitoring the prevalence of such content on social media using computer vision and generative AI (artificial intelligence) can provide valuable data for tobacco regulatory science (TRS).
Methods: We selected 102 Instagram and TikTok videos posted by micro-influencers in 2021-2024 who promoted e-cigarettes alongside posts featuring four themes: cannabis, entertainment, fashion or healthy lifestyle.
Absolute membrane protein abundance of P-glycoprotein, breast cancer resistance protein, and multidrug resistance proteins in term human placenta tissue and commonly used cell systems: Application in physiologically based pharmacokinetic modeling of placental drug disposition.
Drug Metab Dispos
January 2025
Centre for Applied Pharmacokinetic Research, University of Manchester, Manchester, United Kingdom; Certara Predictive Technologies, Sheffield, United Kingdom.
The placenta acts as a barrier, excluding noxious substances while actively transferring nutrients to the fetus, mediated by various transporters. This study quantified the expression of key placental transporters in term human placenta (n = 5) and BeWo, BeWo b30, and JEG-3 placenta cell lines. Combining these results with pregnancy physiologically based pharmacokinetic (PBPK) modeling, we demonstrate the utility of proteomic analysis for predicting placental drug disposition and fetal exposure.
View Article and Find Full Text PDFConflicts of interest in the International Agency for Research on Cancer process of identifying carcinogenic hazards to humans.
Hum Exp Toxicol
January 2025
AnaPath Services GmbH/K. Weber Consulting GmbH, Oberbuchsiten, Switzerland.
Managing conflicts of interest (COIs) in scientific decision-making is important for minimizing bias and fostering public trust in science. Proper management of COIs has added significance when scientists are making decisions that impact public policy, such as assessing substances for carcinogenicity. The International Agency for Research on Cancer (IARC) organizes expert working groups to identify putative carcinogens and determine whether or not the hazard is likely to present significant potential harm to humans.
View Article and Find Full Text PDFPrenatal Per- and Polyfluoroalkyl Substances in Relation to Antibody Titers and Infections in Childhood.
Environ Res
January 2025
Department of Obstetrics and Fetal Medicine, University Medical Center Hamburg-Eppendorf, Hamburg, Germany; German Center for Child and Adolescent Health, Partner Site Hamburg; Hamburg Center for Translational Immunology, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
Background: Per- and polyfluoroalkyl substances (PFAS) are persistent and ubiquitous chemicals posing environmental and health risks. Impact on the human immune system is of particular concern, especially during fetal immune development. Alterations to fetal immune development can impact immunity later in life, e.
View Article and Find Full Text PDFIntracholecystic papillary neoplasm: A case report.
Int J Surg Case Rep
January 2025
Faculty of Medicine of Tunis, Tunis El Manar University, Djebal Lakhdar Street, 1006 Tunis, Tunisia; Department of Pathology, Habib Thameur Hospital, 1082 Tunis, Tunisia. Electronic address:
Introduction And Importance: More needs to be understood concerning the natural progression and visual attributes of intracholecystic papillary neoplasm. Its longevity, especially the rate at which it transitions from benign to malignant growths, remains ambiguous. Consequently, it is imperative to elucidate the intrinsic progression of this precancerous lesion in the gallbladder.
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