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Similar Publications

Mice with Reduced PAR4 Reactivity show Decreased Venous Thrombosis and Platelet Procoagulant Activity.

J Thromb Haemost

January 2025

Case Western Reserve University, School of Medicine, Department of Pharmacology, Cleveland, OH United States. Electronic address:

Background: Hypercoagulation and thrombin generation are major risk factors for venous thrombosis. Sustained thrombin signaling through PAR4 promotes platelet activation, phosphatidylserine exposure, and subsequent thrombin generation. A single-nucleotide polymorphism in PAR4 (rs2227376) changes proline to leucine extracellular loop 3 (P310L), which decreases PAR4 reactivity and is associated with a lower risk for venous thromboembolism (VTE) in a GWAS meta-analysis.

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Usefulness of serial in vivo imaging to directly assess the role of inflammation in thrombus resolution and organization.

Biochem Biophys Res Commun

January 2025

Division of Cardiovascular Medicine, Department of Internal Medicine, Kobe University Graduate School of Medicine, Kobe, Japan; Laboratory of Clinical Pharmaceutical Science, Kobe Pharmaceutical University, Kobe, Japan.

Deep vein thrombosis (DVT) remains a significant health problem. Although animal models have provided significant insights into the DVT pathophysiology, time-course assessment in a same animal is technically limited. Recently, we reported a novel murine saphenous DVT model for in vivo visualization of spatiotemporal dynamics of inflammatory cells.

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Hematologic Complications of Pregnancy.

Eur J Haematol

January 2025

Division of Hematology and Medical Oncology, Oregon Health & Science University, Portland, Oregon, USA.

Hematologic complications are common in pregnancy and can significantly impact both maternal and fetal health. Recognizing and treating these complications can be challenging due to the limited evidence available to guide clinical consultants. Iron deficiency anemia is the most prevalent hematologic issue in pregnancy and often occurs due to increased maternal blood volume and the nutritional demands of the growing fetus.

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Inferior vena cava (IVC) anomalies are rare congenital pathologies related to variations of agenesis, hypoplasia, or atresia, predisposing patients to thromboembolic events secondary to an alteration in venous drainage with resultant stasis. This is a case report of a 27-year-old male without significant medical history presenting for a fall after playing recreational basketball with associated pain and swelling in his left lower extremity. After his symptoms progressively worsened, he came to the emergency room for an evaluation where an ultrasound (US) of the extremity showed extensive deep vein thromboses (DVT).

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[Professor 's clinical experience in treatment of pelvic congestion syndrome with acupuncture].

Zhongguo Zhen Jiu

January 2025

Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing 100700, China; Acupuncture and Moxibustion Hospital of China Academy of Chinese Medical Sciences, Beijing 100700.

The paper introduces Professor 's experience in treating pelvic congestion syndrome with acupuncture. Professor believes that the stagnation in the thoroughfare and conception vessels, retarded circulation of and blood, and the obstruction of blood flow in the uterus are implicated in the pathogenesis of pelvic congestion syndrome. In clinical practice, according to the pathogenesis, focusing on regulating the functions of the thoroughfare and conception vessels, the thinking of treatment is summarized as "resolving the stasis and stopping pain by regulating the thoroughfare and conception vessels", "selecting the points based on their indications" and "tranquilizing the mind and harmonizing the physical and mental states".

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