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Background: Autoimmune pancreatitis (AIP) is a form of chronic pancreatitis that presents clinically with obstructive icterus, histologically with infiltration of pancreatic parenchyma by inflammatory cells leading to chronic inflammation with fibrosis, and therapeutically with good response to corticosteroid therapy. Clinically, it may resemble malignant disease, making diagnosis difficult and requiring a multidisciplinary team (gastroenterologist, endoscopist, radiologist, surgeon, pathologist). Two types of AIP are distinguished.
View Article and Find Full Text PDFAutophagy-dependent hepatocyte secretion of DBI/ACBP induced by glucocorticoids determines the pathogenesis of cushing syndrome.
Autophagy
December 2024
Metabolomics and Cell Biology Platforms, UMS AMMICa, Gustave Roussy Institut, Villejuif, France.
DBI/ACBP is a phylogenetically ancient hormone that stimulates appetite and lipo-anabolism. In response to starvation, DBI/ACBP is secreted through a noncanonical, macroautophagy/autophagy-dependent pathway. The physiological hunger reflex involves starvation-induced secretion of DBI/ACBP from multiple cell types.
View Article and Find Full Text PDFDermatological dichotomy: Atopic dermatitis or mycosis fungoides?
Asia Pac Allergy
December 2024
Allergy and Clinical Immunology Department, Coimbra University Hospital Centre, Coimbra, Portugal.
Article Synopsis
- Atopic dermatitis (AD) and mycosis fungoides (MF) can be difficult to distinguish because they exhibit similar symptoms like inflamed and itchy skin lesions.
- A case study of a 19-year-old male with a past AD history highlights the diagnostic confusion when he developed atypical eczema-like lesions that required advanced testing to confirm MF after initial misdiagnosis.
- The case underscores the importance of accurate and early diagnosis to differentiate between AD and MF, as MF requires specific treatments, and it encourages further research into shared mechanisms for improved patient care.
[Early onset leukoencephalopathy with vanishing white matter].
Rev Neurol
November 2024
Hospital Clínico Universitario de Valencia, 46010 Valencia, España.
Introduction: Leukodystrophies are a group of developmental disorders of the white matter in the central nervous system. Their differential diagnosis is very broad, and as such information from neuroimaging can be very useful. We present the case of an infant diagnosed with leukoencephalopathy with vanishing white matter following neurological regression.
View Article and Find Full Text PDFMultiple Pyoderma Gangrenosum Overlying AV Fistula Treated With Colchicine: A Case Report.
Can J Kidney Health Dis
October 2024
Département de Médecine, Hôpital du Sacré-Coeur de Montréal, QC, Canada.
Article Synopsis
- - Pyoderma gangrenosum (PG) is a rare condition that causes painful ulcers, which can occur after trauma like needle insertion, a phenomenon known as pathergy; this report highlights a 69-year-old woman who developed PG after hemodialysis.
- - The patient experienced painful ulcers at the site of needle insertion on her arteriovenous fistula (AVF), prompting a diagnosis of PG following a thorough evaluation that ruled out other causes.
- - Treatment involved suspending dialysis through the AVF and using medications such as prednisone, topical corticosteroids, and colchicine to manage PG; her condition improved, allowing for safe resumption of dialysis while minimizing the risk of further complications.
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