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Background: Regionally anticoagulated continuous renal replacement therapy with citrate is the first choice for critically ill patients with acute kidney injury. If citrate that reaches the patient exceeds the metabolic capacity, metabolic alkalosis will follow. Bicarbonate from the treatment fluids will also reach the patient and add to the bicarbonate load.
View Article and Find Full Text PDFCD44-Receptors-Mediated Multiprong Targeting Strategy Against Breast Cancer and Tumor-Associated Macrophages: Design, Optimization, Characterization, and Cytologic Evaluation.
Int J Nanomedicine
January 2025
Department of Pharmaceutics, College of Pharmacy, King Saud University, Riyadh, 11451 Saudi Arabia.
Introduction: Owing to its high prevalence, colossal potential of chemoresistance, metastasis, and relapse, breast cancer (BC) is the second leading cause of cancer-related fatalities in women. Several treatments (eg, chemotherapy, surgery, radiations, hormonal therapy, etc.) are conventionally prescribed for the treatment of BC; however, these are associated with serious systemic aftermaths.
View Article and Find Full Text PDFEnhancing a Perovskite Solar Cell and Module by Suppressing Protonation through Chelating Agents.
ACS Appl Mater Interfaces
January 2025
Institute of New Energy Technology, College of Physics and Optoelectronic Engineering, Jinan University, Guangzhou 510632, Guangdong, China.
Formamidinium-based perovskites (FA perovskites) often incorporate methylammonium chloride (MACl) to stabilize the α-FAPbI phase and prevent formation of the δ phase. However, MACl undergoes deprotonation and reacts with FA, leading to the generation of unstable byproducts that can cause component degradation and negatively impact the device performance. In this study, we introduce ethylenediaminetetramethylenephosphonic acid as a corrosion inhibitor, which effectively prevents the formation of these byproducts and stabilizes α-FAPbI.
View Article and Find Full Text PDFThe mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake.
Nat Commun
January 2025
Institute of Medical Microbiology, University of Zurich, Zurich, Switzerland.
The mycobacterial ABC transporter IrtAB features an ABC exporter fold, yet it imports iron-charged siderophores called mycobactins. Here, we present extensive cryo-EM analyses and DEER measurements, revealing that IrtAB alternates between an inward-facing and an outward-occluded conformation, but does not sample an outward-facing conformation. When IrtAB is locked in its outward-occluded conformation in nanodiscs, mycobactin is bound in the middle of the lipid bilayer at a membrane-facing crevice opening at the heterodimeric interface.
View Article and Find Full Text PDFEstablishment of a Mouse Model with Cough Hypersensitivity via Inhalation of Citric Acid.
J Vis Exp
January 2025
State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University;
Cough is one of the most common symptoms of many respiratory diseases. Chronic cough significantly impacts quality of life and imposes a considerable economic burden. Increased cough sensitivity is a pathophysiological hallmark of chronic cough.
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