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Chimeric antigen receptor (CAR) T-cell products axicabtagene ciloleucel (axi-cel), tisagenlecleucel (tisa-cel), and lisocabtagene maraleucel (liso-cel) are approved for relapsed/refractory large B-cell lymphoma (R/R LBCL). Emerging evidence indicates that delayed CAR T-cell infusion, including prolonged time from leukapheresis to infusion, known as vein-to-vein time (V2Vt), may adversely impact clinical outcomes. We conducted a systematic literature review (SLR) and meta-analysis to identify differences in V2Vt in patients with R/R LBCL treated with axi-cel, tisa-cel, or liso-cel.
View Article and Find Full Text PDFIdentification of Intracranial Germ Cell Tumors Based on Facial Photos: Exploratory Study on the Use of Deep Learning for Software Development.
J Med Internet Res
January 2025
Department of Radiation Oncology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Background: Primary intracranial germ cell tumors (iGCTs) are highly malignant brain tumors that predominantly occur in children and adolescents, with an incidence rate ranking third among primary brain tumors in East Asia (8%-15%). Due to their insidious onset and impact on critical functional areas of the brain, these tumors often result in irreversible abnormalities in growth and development, as well as cognitive and motor impairments in affected children. Therefore, early diagnosis through advanced screening techniques is vital for improving patient outcomes and quality of life.
View Article and Find Full Text PDFComparison of 3 Aging Metrics in Dual Declines to Capture All-Cause Dementia and Mortality Risk: Cohort Study.
JMIR Aging
January 2025
Department of Geriatrics, Guangdong Provincial Geriatrics Institute, Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Southern Medical University, No. 106, Zhongshan 2nd Road, Yuexiu District, Guangzhou, China, 0898-66571684.
Background: The utility of aging metrics that incorporate cognitive and physical function is not fully understood.
Objective: We aim to compare the predictive capacities of 3 distinct aging metrics-motoric cognitive risk syndrome (MCR), physio-cognitive decline syndrome (PCDS), and cognitive frailty (CF)-for incident dementia and all-cause mortality among community-dwelling older adults.
Methods: We used longitudinal data from waves 10-15 of the Health and Retirement Study.
Essential Primary Health Care Skills: Virtual Simulations for Nurse Practitioner Education.
Nurse Educ
January 2025
Author Affiliations: Daphne Cockwell School of Nursing (Dr Ziegler, Ms Dickson), Toronto Metropolitan University, Toronto, Ontario, Canada; School of Nursing (Dr Silva), Brock University, St. Catherines, Ontario, Canada; School of Nursing (Dr Pirani), University of Victoria, Victoria, British Columbia, Canada; School of Nursing (Dr Tyerman), University of Ottawa, Ottawa, Ontario, Canada; and School of Nursing (Dr Luctkar-Flude), Queens University, Kingston, Ontario, Canada.
Background: Practice-based learning is essential in nurse practitioner (NP) education to ensure public safety and prepare students for independent practice. However, lack of clinical placement opportunities results in variability in clinical experience, necessitating educational innovation.
Purpose: To evaluate the usability, engagement, and impact of the Essential Skills for Nurse Practitioners virtual simulations (VS).
Coevolutionary dynamics in the grass-livestock social-ecological system of China's alpine pastoral areas: A case study of the Qilian Mountains region in China.
PLoS One
January 2025
Department of Geography, University College London, London, England, United Kingdom.
Evaluating the dynamic co-evolution and feedback mechanisms within socio-ecological systems is crucial for determining the resilience and sustainability of environmental governance strategies. The grass-livestock system, as a complex entity encompassing livestock nutrition, foraging behavior, vegetation ecology, pastoralists' economic income, and policy interventions, indicates that any change in a single element may trigger a chain reaction within the system. This paper uses a system dynamics approach to construct a simulation model of the grass-livestock system in alpine pastoral areas, simulating the long-term dynamic co-evolution of the socio-ecological system in the Qilian Mountains region of China.
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