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Flexible Tactile Sensors with Self-Assembled Cilia Based on Magnetoelectric Composites.
ACS Appl Mater Interfaces
January 2025
School of Precision Instrument and Optoelectronics Engineering, Tianjin University, 92 Weijin Road, Tianjin 300072, China.
Traditional tactile sensors are single-function, and it is difficult to meet the needs of applications in complex environments. This paper describes the development and applications of flexible tactile sensors with cilia based on magnetoelectric composites made of neodymium iron boron (NdFeB) microparticles with a silver (Ag) nanoshell in polydimethylsiloxane (PDMS). These sensors adopt the inherent magnetism of NdFeB microparticles and the excellent conductivity of the Ag coating.
View Article and Find Full Text PDFStructural basis for metal ion transport by the human SLC11 proteins DMT1 and NRAMP1.
Nat Commun
January 2025
Department of Biochemistry, University of Zurich, Zurich, Switzerland.
Iron and manganese are essential nutrients whose transport across membranes is catalyzed by members of the SLC11 family. In humans, this protein family contains two paralogs, the ubiquitously expressed DMT1, which is involved in the uptake and distribution of Fe and Mn, and NRAMP1, which participates in the resistance against infections and nutrient recycling. Despite previous studies contributing to our mechanistic understanding of the family, the structures of human SLC11 proteins and their relationship to functional properties have remained elusive.
View Article and Find Full Text PDFThe temperature dependence of Mössbauer quadrupole splitting values: a quantum chemical analysis.
Chem Commun (Camb)
January 2025
Department of Chemistry, Quantum Chemistry, TU Darmstadt, Peter-Grünberg-Str. 4, 64287 Darmstadt, Germany.
The two key parameters extracted from Mössbauer spectroscopy, isomer shift and quadrupole splitting, have well-known temperature dependencies. While the behavior of the values following a temperature change has long been known, its microscopic origins are less clear. For quantum chemical calculations - formally representing the situation at 0 K - significant discrepancies with the experiment can arise, especially at elevated temperatures.
View Article and Find Full Text PDFMRI-Based Multifunctional Nanoliposomes for Enhanced HCC Therapy and Diagnosis.
Mol Pharm
January 2025
Key Laboratory of Natural Medicines of the Changbai Mountain, Ministry of Education, College of Pharmacy, Yanbian University, Yanji 133002, China.
The morbidity and mortality rates of hepatocellular carcinoma (HCC) are high and continue to increase. The antitumor effects of single therapies are limited because of tumor heterogeneity and drug resistance, and the lack of real-time monitoring of tumor progression during the treatment process leads to poor therapeutic outcomes. Therefore, novel nanodelivery platforms combining tumor therapy and diagnosis have garnered extensive attention.
View Article and Find Full Text PDFA mitochondrion-targeted poly(N-isopropylacrylamide-coacrylic acid) nanohydrogel with a fluorescent bioprobe for ferrous ion imaging in vitro and in vivo.
Spectrochim Acta A Mol Biomol Spectrosc
January 2025
School of Pharmacy, Hangzhou Medical College, Hangzhou, Zhejiang 310007, China; Department of Medicine, Zhejiang Academy of Traditional Chinese Medicine, Hangzhou, Zhejiang 310007, China. Electronic address:
An imbalance in iron homeostasis contributes to mitochondrial dysfunction, which is closely linked to the pathogenesis of various diseases. Herein, we developed a nanosensor for detecting mitochondrial ferrous ions in vitro and in vivo. A poly(N-isopropylacrylamine)-coacrylic acid nanohydrogel was synthesized, and ferrous ions were detected using the fluorescent probe FeRhonox-1 embedded within it.
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