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Treatment challenges in the management of difficult-to-treat gram-positive infections: A consensus view apropos therapeutic role of novel anti-MRSA antibiotics, levonadifloxacin (IV) and alalevonadifloxacin (oral).
Indian J Med Microbiol
March 2024
Department of Clinical Microbiology, Christian Medical College, Vellore, India.
Purpose: Treatment of antibiotic-resistant Gram-positive infections (GPIs), including methicillin-resistant Staphylococcus aureus (MRSA) is becoming increasingly difficult, particularly in patients with multiple co-morbidities who require antibiotics with greater safety and a consistent pharmacokinetic/pharmacodynamic (PK/PD) profile. Such difficult-to-treat GPIs are often associated with poor outcomes, extended hospital stay and increased expenditure. This can be partly attributed to the limited safety and aberrant PK/PD profile of existing anti-MRSA antibiotics.
View Article and Find Full Text PDFWisdom lies in applying critical clinical judgment that delves deeper than mere appearances. Apropos of a case of ventricular hypertrophy.
Rev Esp Cardiol (Engl Ed)
December 2023
Unidad de Cardiopatías Familiares y Unidad Multidisciplinar de Amiloidosis TTR, Servicio de Cardiología, Hospital Universitario Son Llàtzer, Instituto de Investigación Sanitaria de las Islas Baleares (IdISBa), Palma de Mallorca, Islas Baleares, Spain. Electronic address:
Structural heart disease: one valve does not fit all.
Curr Opin Support Palliat Care
March 2019
University Hospitals Cleveland Medical Center/Harrington Heart & Vascular Institute, Cleveland, Ohio, USA.
Purpose Of Review: Highlight the difficulties patients, physicians, and the global economy face in relation to treatment of structural heart diseases. It is easy to be carried away by the excitement of medical advancement; however, it is difficult to demonstrate restraint. Transcatheter aortic valve replacement (TAVR) is a modern marvel that can help many patients when utilized appropriately.
View Article and Find Full Text PDFOverdistribution illusions: Categorical judgments produce them, confidence ratings reduce them.
J Exp Psychol Gen
January 2017
Department of Psychology, University of Leicester.
Overdistribution is a form of memory distortion in which an event is remembered as belonging to too many episodic states, states that are logically or empirically incompatible with each other. We investigated a response formatting method of suppressing 2 basic types of overdistribution, disjunction and conjunction illusions, which parallel some classic illusions in the judgment and decision making literature. In this method, subjects respond to memory probes by rating their confidence that test cues belong to specific episodic states (e.
View Article and Find Full Text PDFAction reflections: a client-centered technique to bridge the WHY-HOW transition in Motivational Interviewing.
Behav Cogn Psychother
July 2012
University of Michigan, School of Public Health, 109 Observatory Street, Room 3867 SPH I, Ann Arbor, MI 48109-2029, USA.
Background: When using Motivational Interviewing (MI), once resistance or ambivalence are resolved and motivation is solidified, many practitioners struggle with how best to transition the discussion toward action planning, while still retaining the spirit and style of client centeredness, i.e., moving from the WHY phase to the HOW phase of counseling in a style that is MI-consistent.
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