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Relationship between high-resolution computed tomography quantitative imaging analysis and physiological and clinical features in antisynthetase syndrome-related interstitial lung disease.
RMD Open
November 2024
Department of Medicine, Division of Rheumatology and Clinical Immunology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA
Objectives: To explore the association between the extent of CT abnormalities by quantitative imaging analysis (QIA) and clinical/physiological disease parameters in patients with antisynthetase syndrome associated interstitial lung disease (ARS-ILD).
Methods: We analysed 20 patients with antisynthetase antibodies and active ILD enrolled in the Abatacept in Myositis-Associated Interstitial Lung Disease study. High-resolution chest CT was obtained at weeks 0, 24 and 48 and QIA scored the extent of ground glass (quantitative score for ground glass), fibrosis (quantitative score for lung fibrosis, QLF) and total ILD (quantitative ILD, QILD).
Article Synopsis
- Muscle relaxants like rocuronium can be risky for patients with conditions such as polymyositis, particularly in cases that are not fully controlled.
- This report outlines a case where a 27-year-old woman with controlled polymyositis underwent minor surgery, requiring careful monitoring of her neuromuscular function during and after the use of rocuronium and sugammadex.
- Findings suggest prolonged muscle relaxation effects, attributed to decreased muscle volume in polymyositis patients, highlighting the need for close supervision in such surgical settings.
FDG PET/CT Findings of Rapidly Progressive Interstitial Lung Disease in a Patient With Anti-MDA5 Dermatomyositis.
Clin Nucl Med
January 2025
Department of Nuclear Medicine, The First Affiliated Hospital of Naval Medical University, Shanghai, China.
Article Synopsis
- - Anti-MDA5 dermatomyositis can lead to a severe form of lung disease known as rapidly progressive interstitial lung disease, which has a high risk of mortality.
- - A case report describes the imaging findings from a patient using FDG PET/CT, revealing bilateral ground-glass opacities and varying FDG activity that can resemble infectious pneumonia.
- - Recognizing these specific imaging characteristics is crucial for diagnosing this type of lung disease and ensuring effective treatment.
Dermatomyositis Associated With High-Grade B-Lymphoproliferative Disorders: A Case Report and Literature Review.
J Investig Med High Impact Case Rep
July 2024
Canberra Hospital, ACT, Australia.
Dermatomyositis (DM) and polymyositis are idiopathic inflammatory myopathies (IIMs), most associated with solid organ malignancies, and less commonly hematological malignancies. We discuss a case of DM associated with diffuse large B-cell lymphoma, followed by a review of literature on the pathogenesis, clinical course, treatment, and prognosis. Various challenges with the diagnosis and management of underlying lymphoproliferative disorders (LPDs) in patients with IIM are discussed.
View Article and Find Full Text PDFCase report: "Fur stole and turtleneck" and "halter-back" signs: an expanded wardrobe for dermatomyositis.
Front Immunol
June 2024
Department of Medicine, The University of the West Indies, Mona, Kingston, Jamaica.
A diagnosis of dermatomyositis requires recognition of distinct patterns of skin disease in combination with, and sometimes without, muscle weakness. Often, a striking contrast between involved and uninvolved areas is observed. Familiar patterns include eyelid and midfacial eruptions, Gottron papules/sign, and upper back (shawl sign), central chest (V/open collar sign), and lateral thigh (holster sign) involvement.
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