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GnRH-Gonadotropes Interactions Revealed by Pituitary Single-cell Transcriptomics in Zebrafish.
Endocrinology
October 2024
Institute of Marine & Environmental Technology, Department of Marine Biotechnology, University of Maryland Baltimore County, Baltimore, MD 21202, USA.
GnRH governs reproduction by regulating pituitary gonadotropins. Unlike most vertebrates, gnrh-/- zebrafish are fertile. To elucidate the role of the hypophysiotropic-Gnrh3 and other mechanisms regulating pituitary gonadotropes, we profiled the gene expression of all individual pituitary cells of wild-type and gnrh3-/- adult female zebrafish.
View Article and Find Full Text PDFLong Noncoding RNAs Expressed in Mouse Pituitary Development and Mature Hormone-Producing Cells.
Endocrinology
October 2024
Department of Human Genetics, University of Michigan, Ann Arbor, MI 41809-5618, USA.
Mammalian genomes contain thousands of genes for long noncoding RNA (lncRNAs), some of which have been shown to affect protein coding gene expression through diverse mechanisms. The lncRNA transcripts are longer than 200 nucleotides and are often capped, spliced, and polyadenylated, but not translated into protein. Nuclear lncRNAs can modify chromatin structure and transcription in trans or cis by interacting with the DNA, forming R-loops, and recruiting regulatory proteins.
View Article and Find Full Text PDFCharacterization of gonadotropins and their receptors in a chondrichthyan, Scyliorhinus canicula, fills a gap in the understanding of their coevolution.
Gen Comp Endocrinol
November 2024
Université de Caen Normandie, MNHN, SU, UA, CNRS, IRD, Laboratoire de Biologie des Organismes et Ecosystèmes Aquatiques (BOREA), UMR 8067, 14032 Caen cedex 5, France. Electronic address:
Article Synopsis
- - The hypothalamic-pituitary-gonadal (HPG) axis regulates reproduction in gnathostomes, involving gonadotropins like FSH and LH that interact with their specific receptors in gonads; however, research on these in chondrichthyes (sharks and rays) is limited.
- - This study identified gonadotropin and receptor sequences in chondrichthyan genomes, analyzed their structures compared to humans, and built 3D interaction models, emphasizing the role of the receptor hinge for ligand recognition.
- - Expression analysis showed that FSHR and LHR are active throughout spermatogenesis in various testicular cells, with high levels of FSHR transcripts in testis and
Identification of Environmental Compounds That May Trigger Early Female Puberty by Activating Human GnRHR and KISS1R.
Endocrinology
August 2024
Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA.
There has been an alarming trend toward earlier puberty in girls, suggesting the influence of an environmental factor(s). As the reactivation of the reproductive axis during puberty is thought to be mediated by the hypothalamic neuropeptides kisspeptin and gonadotropin-releasing hormone (GnRH), we asked whether an environmental compound might activate the kisspeptin (KISS1R) or GnRH receptor (GnRHR). We used GnRHR or KISS1R-expressing HEK293 cells to screen the Tox21 10K compound library, a compendium of pharmaceuticals and environmental compounds, for GnRHR and KISS1R activation.
View Article and Find Full Text PDFDevelopmental exposure to environmentally relevant doses of phthalates alters the neural control of male and female reproduction in mice.
Environ Res
October 2024
Sorbonne Université, CNRS UMR 8246, INSERM U1130, Neuroscience Paris Seine - Institut de Biologie Paris Seine, 75005, Paris, France. Electronic address:
The present study aims to analyze the effects of developmental exposure to phthalates at environmentally relevant doses on the neural control of male and female reproduction. For this purpose, C57Bl/6J mice were exposed to di-(2-ethylexyl) phthalate (DEHP) alone (5 or 50 μg/kg/d), or DEHP (5 μg/kg/d) in a phthalate mixture. Exposure through diet started 6 weeks before the first mating and lasted until weaning of litters from the second gestation (multiparous dams).
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