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http://dx.doi.org/10.1136/bmj.2.5476.1471 | DOI Listing |
Proc Natl Acad Sci U S A
January 2025
Department of Molecular & Cellular Biosciences, University of Cincinnati, Cincinnati, OH 45267.
TGFβ family ligands are synthesized as precursors consisting of an N-terminal prodomain and C-terminal growth factor (GF) signaling domain. After proteolytic processing, the prodomain typically remains noncovalently associated with the GF, sometimes forming a high-affinity latent procomplex that requires activation. For the TGFβ family ligand anti-Müllerian hormone (AMH), the prodomain maintains a high-affinity interaction with its GF that does not render it latent.
View Article and Find Full Text PDFStaphylococcus aureus prosthetic joint infections (PJIs) are broadly considered incurable, and clinical diagnostics that guide conservative vs. aggressive surgical treatments do not exist. Multi-omics studies in a humanized NSG-SGM3 BLT mouse model demonstrate human T cells: 1) are remarkably heterogenous in gene expression and numbers, and 2) exist as a mixed population of activated, progenitor-exhausted, and terminally-exhausted Th1/Th17 cells with increased expression of immune checkpoint proteins (LAG3, TIM-3).
View Article and Find Full Text PDFCureus
December 2024
Department of Physiology and Anatomy, University of North Texas Health Science Center, Fort Worth, USA.
The facial and transverse facial arteries supply blood to the superficial structures of the face. Understanding these arterial variations is essential for optimizing surgical planning and outcomes, especially in invasive facial procedures. A 78-year-old male cadaveric dissection documented variations in facial and transverse facial arteries.
View Article and Find Full Text PDFInt J Surg Pathol
January 2025
Pathology Department, Complejo Asistencial Universitario de León, León, Spain.
The persistence of fetal vitelline structures may occur. The primary intestinal arterial supply development happens normally in this scenario, but a vitelline vascular remnant (VVR) persists. A 13-year-old boy with a history of severe and intermittent abdominal pain since early infancy presented to the Emergency Department with clinical, analytical, and ultrasonographic findings suggestive of acute appendicitis.
View Article and Find Full Text PDFBMJ Open Qual
January 2025
Mayo Clinic, Rochester, Minnesota, USA.
Background: The Scientific Registry for Transplant Recipients (SRTR) publishes outcomes of all transplant centres in the USA two times a year. The outcomes are publicly available and used by insurance payers and patients to assess the performance of a programme. Poor performance can result in temporary suspension or termination of a transplant programme.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!