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Platelets as crucial players in the dynamic interplay of inflammation, immunity, and cancer: unveiling new strategies for cancer prevention.
Front Pharmacol
December 2024
Systems Pharmacology and Translational Therapeutics Laboratory, The Center for Advanced Studies and Technology (CAST), "G. d'Annunzio" University, Chieti, Italy.
Inflammation plays a critical role in the pathogenesis of various diseases by promoting the acquisition of new functional traits by different cell types. Shared risk factors between cardiovascular disease and cancer, including smoking, obesity, diabetes, high-fat diet, low physical activity, and alcohol consumption, contribute to inflammation linked to platelet activation. Platelets contribute to an inflammatory state by activating various normal cells, such as fibroblasts, immune cells, and vascular cells.
View Article and Find Full Text PDFUniversity students' health-related quality of life and its determinants. Results from a cross-sectional survey during the COVID-19 pandemic.
PLoS One
January 2025
Institute for Medical Epidemiology, Biometrics and Informatics (IMEBI), Interdisciplinary Center for Health Sciences, Medical School of the Martin Luther University Halle-Wittenberg, Halle (Saale), Germany.
Being a university student is a vulnerable period marked by transitions and uncertainties which can impair their physical and mental well-being as well as overall quality of life. The existing literature suggests that certain groups of students might be particularly affected by that. In addition, quality of life might have been further affected by the COVID-19 pandemic.
View Article and Find Full Text PDFHydrogen storage properties of TiFe-based composite with Ni addition.
Heliyon
December 2024
School of Materials Science and Engineering, Inner Mongolia University of Science and Technology, Baotou, 014010, China.
This paper presents the preparation of the parental experimental alloy, featuring a standard composition of TiYZrFeNiMn, via the vacuum induction melting technique. Subsequently, the TiYZrFeNiMn alloy, with an addition of 2 wt% Ni, underwent mechanical ball milling to yield a TiFe-based composite for experimental purposes. The results of the experimental tests indicate that the composite alloy's phase composition comprises the TiFe primary phase, with a minor quantity of ZrMn phase segregated on the surface of the primary TiFe phase, as well as Ni phase.
View Article and Find Full Text PDFAnthelmintic Potential of Conjugated Long-Chain Fatty Acids Isolated from the Bioluminescent Mushroom .
J Nat Prod
January 2025
Department of Chemistry, Federal University of Piaui, Campus Ministro Petrônio Portela, Teresina, PI 64049-550, Brazil.
With praziquantel being the sole available drug for schistosomiasis, identifying novel anthelmintic agents is imperative. A chemical investigation of the fruiting body of the bioluminescent mushroom Berk. resulted in the isolation of new conjugated long-chain fatty acids (8,10,12,13)-12,13-dihydroxy-7-oxo-octadeca-8,10-dienoic acid () and (7,8,9,11)-7,8-dihydroxy-13-oxo-octadeca-9,11-dienoic acid () and three previously described compounds, (7,8,9)-7,8-dihydroxyoctadec-9-enoic acid (), (2)-dec-2-ene-1,10-dioic acid (), and a ketolactone marasmeno-1,15-dione ().
View Article and Find Full Text PDFN1 facilitation at short Inter-Stimulus-Interval (ISI) occurs under 400 ms and is dependent on ISI from previous sounds: Evidence using an unpredictable auditory stimulation sequence.
Int J Psychophysiol
December 2024
Clinical Neurophysiology Research Laboratory, Western Psychiatric Hospital, Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
The N1 auditory evoked potential amplitude depends heavily on the inter-stimulus interval (ISI). Typically, shorter ISIs result in reduced N1 amplitudes, suggesting a decreased neural response with high stimulus presentation rates. However, an exception known as N1 facilitation occurs with very brief ISIs (∼150-500 ms), where the N1 amplitude increases.
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