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Vitamin D receptor polymorphisms associate with the efficacy and toxicity of radioiodine-131 therapy in patients with differentiated thyroid cancer.
Cancer Biomark
October 2024
Department of Neurology, Chenzhou First People's Hospital, Chenzhou, China.
Background: Radioiodine-131 (I-131) therapy is the common postoperative adjuvant therapy for differentiated thyroid cancer (DTC) However, methods to evaluate the efficacy and toxicity of I-131 on DTC are still lacking.
Objective: To evaluate the association between vitamin D receptor (VDR) gene polymorphisms and the efficacy and toxicity of I-131 in DTC patients.
Methods: A total of 256 DTC patients who received I-131 therapy were enrolled.
IL-6 and IL-10 Levels in Rats Blood Plasma as Immune Responses Post Radioiodine (I-131) Administration.
Asian Pac J Cancer Prev
March 2024
Directorate of Nuclear Facility Management, National Research and Innovation Agency, Serpong, Indonesia.
Objective: The purpose of this study was to analyze the effect of oral administration of radioiodine (I-131) on the immune responses (interleukin 6 and 10) as biodosimetry markers and to support clinical trials of I-131 solution.
Methods: The design of this study was an in vivo experimental study using twenty-seven male rats (Rattus norvegicus strain Sprague-Dawley) given 100 μL of I-131 solution at a dose of 260 μCi. Blood plasma was taken at 0.
Radioiodine whole body scan pitfalls in differentiated thyroid cancer.
Endocrine
August 2024
Division of Endocrinology and Diabetes Prevention and Care, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Article Synopsis
- Whole body scans (WBS) using I-131 can help monitor patients with differentiated thyroid cancer but can yield false positives due to non-tumor conditions.
- A study analyzed 370 cases of false uptake, finding that most originated from non-tumoral diseases (55.1%) and benign tumors (29.5%), with a notable occurrence in various body regions.
- To ensure accurate diagnosis, it’s essential to interpret WBS results alongside patient history, serum thyroglobulin levels, and additional medical tests.
Unraveling the mechanism of iodate adsorption by anthocyanin-rich fruit waste as green adsorbents for Applications of radioactive iodine remediation in water environment.
Environ Res
June 2024
School of Bio-Chemical Engineering and Technology, Sirindhorn International Institute of Technology (SIIT), Thammasat University, P.O Box 22, Pathum Thani 12121, Thailand. Electronic address:
In aquatic settings, radioactive iodine from nuclear waste can exist as iodate (IO). This study explored the efficiency and mechanism of IO adsorption by minimally modified anthocyanin-based adsorbents. Pomegranate peels and mangosteen pericarps were selected from an initial screening test and could remove over 70% of 10 mg/L IO.
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