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The known genetic variants of BRCA1, BRCA2 and NOD2 in pancreatitis and pancreatic cancer risk assessment.
Sci Rep
January 2025
Institute of Medical Sciences, Jan Kochanowski University of Kielce, Kielce, Poland.
The single nucleotide polymorphism in NOD2 (rs2066847) is associated with conditions that may predispose to the development of gastrointestinal disorders, as well as the known BRCA1 and BRCA2 variants classified as risk factors in many cancers. In our study, we analyzed these variants in a group of patients with pancreatitis and pancreatic cancer to clarify their role in pancreatic disease development. The DNA was isolated from whole blood samples of 553 patients with pancreatitis, 83 patients with pancreatic cancer, 44 cases of other pancreatic diseases, and 116 healthy volunteers.
View Article and Find Full Text PDFSecurity Evaluation of Provably Secure ECC-Based Anonymous Authentication and Key Agreement Scheme for IoT.
Sensors (Basel)
January 2025
School of Electronic and Electrical Engineering, Kyungpook National University, Daegu 41566, Republic of Korea.
The proliferation of the Internet of Things (IoT) has worsened the challenge of maintaining data and user privacy. IoT end devices, often deployed in unsupervised environments and connected to open networks, are susceptible to physical tampering and various other security attacks. Thus, robust, efficient authentication and key agreement (AKA) protocols are essential to protect data privacy during exchanges between end devices and servers.
View Article and Find Full Text PDFEvaluating the effectiveness of different intervention measures for an outbreak of mycoplasma pneumoniae in hangzhou based on a dynamic model.
Sci Rep
January 2025
Zhejiang Province Center for Disease Control and Prevention, Hangzhou, 310051, Zhejiang Province, China.
For Mycoplasma pneumoniae (MP) infection in schools, the local Center for Disease Control and Prevention recommends nonpharmaceutical interventions, such as case isolation, school closures, suspension of group activities, reinforcement of ventilation and disinfection for influenza outbreaks. However, there is limited evidence supporting and evaluating the effectiveness of these interventions. On the basis of an outbreak of MP infection occurring in a primary school in Zhejiang Province, a susceptible-latent-overt infected-recessive infected-displaced (SEIAR) model was constructed to quantitatively evaluate the prevention and control effects by simulating the intervention measures mentioned above.
View Article and Find Full Text PDFInfections among adults hospitalized in intensive care after the 2023 earthquake in the southeastern part of Türkiye: a multi-center observational study.
BMC Infect Dis
January 2025
Department of Internal Medicine, Division of Intensive Care Medicine, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
Background: Scarce evidence is available on the epidemiology of microbiologically proven clinical infections in patients admitted to the intensive care unit (ICU) after a great earthquake. The main aim of this study was to assess clinical infections and microbiological features in patients admitted to the ICU following the 2023 earthquake in the southeastern region of Türkiye with a focus on the timing of culture positivity during their ICU stay. The secondary objectives included determining antibiotic susceptibility patterns, identifying the types of antibiotics administered upon ICU admission, evaluating the appropriateness of antibiotic usage, assessing patient outcomes, and identifying factors that influence microbiologically confirmed clinical infections.
View Article and Find Full Text PDFIsolation and characterization of ɸEcM-vB1 bacteriophage targeting multidrug-resistant Escherichia coli.
BMC Res Notes
January 2025
Department of Microbiology and Immunology, Faculty of Pharmacy, Damanhour University, Damanhour, Egypt.
Objectives: The aim of this study is to screen for, isolate and characterize a bacteriophage designated ɸEcM-vB1 with confirmed lytic activity against multidrug-resistant (MDR) E. coli. Methods done in this research are bacteriophage isolation, purification, titer determination, bacteriophage morphology, host range determination, bacteriophage latent period and burst size determination, genomic analysis by restriction enzymes, and bacteriophage total protein content determination.
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