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Total Contact Casting Remains an Effective Modality for Treatment of Diabetic Foot Ulcers.
Vasc Endovascular Surg
November 2024
Hyperbaric and Advanced Wound Healing Center, NYU Grossman School of Medicine, New York, NY, USA.
Article Synopsis
- * The study found that patients without healing had significantly higher rates of amputation and noncompliance compared to those whose ulcers healed, highlighting the importance of TCC adherence in treatment success.
- * Subgroup analysis revealed that patients undergoing revascularization interventions had better healing outcomes (66.7% healed) and noted lower ABI scores, indicating more severe vascular issues, compared to those who did not require additional procedures. *
Etrinabdione (VCE-004.8), a B55α activator, promotes angiogenesis and arteriogenesis in critical limb ischemia.
J Transl Med
November 2024
Maimonides Biomedical Research Institute of Córdoba (IMIBIC), University of Córdoba, Avda Menéndez Pidal s/n, 14004, Córdoba, Spain.
Background: Vasculogenic therapies explored for the treatment of peripheral artery disease (PAD) have encountered minimal success in clinical trials. Addressing this, B55α, an isoform of protein phosphatase 2A (PP2A), emerges as pivotal in vessel remodeling through activation of hypoxia-inducible factor 1α (HIF-1α). This study delves into the pharmacological profile of VCE-004.
View Article and Find Full Text PDFVariance investigation on the microstructural characteristics of vessels among three lignocellulosic biomasses.
Sci Rep
October 2024
Department of Wood and Forest Sciences, Laval University, Quebec, G1V 0A6, Canada.
Especially, the processing and utilization of biomass-based material is closely related to the vessel, e.g. the flow of vapour and additive.
View Article and Find Full Text PDFIn Vivo Assessment on Freeze-Cast Calcium Phosphate-Based Scaffolds with a Selective Cell/Tissue Ingrowth.
ACS Appl Mater Interfaces
October 2024
Central European Institute of Technology, Brno University of Technology, Purkynova 656/123, 612 00 Brno, Czech Republic.
Highly porous bioceramic scaffolds are widely used as bone substitutes in many applications. However, the use of bioceramics is often limited to hard tissues due to the risk of potential soft tissue calcification. A further limitation of highly porous bioceramic scaffolds is their poor mechanical stability, manifested by their tendency to break under stress.
View Article and Find Full Text PDFNested Semi-Transparent Isosurface Simulated Volume-Rendering (NESTIS-VR) - An efficient on-device rendering approach for Augmented Reality headsets increasing surgeon confidence of kidney donor arterial anatomy.
Comput Biol Med
December 2024
Incubator for Medical Mixed Reality at Stanford (IMMERS), Department of Radiology, Stanford University, Palo Alto, CA, USA; Department of Radiology, Stanford University, Palo Alto, CA, USA.
Background And Objective: Volume-renderings of computed tomography or magnetic resonance angiograms (MRAs) are routinely used by surgeons in the preoperative assessment of vascular anatomy in kidney donors. Stereoscopic headsets (OST-HMD) like Microsoft HoloLens allow intuitive interaction with three-dimensional content for more intuitive comprehension, but do not allow real-time ray-casting volume-rendering of medical volume datasets on-device due to computational limitations.
Methods: We introduce NEsted Semi-Transparent Isosurface Simulated Volume-Rendering (NESTIS-VR), as an on-device alternative to ray-casting volume-rendering and developed an application for HoloLens to render kidney donor MRAs with interactive control of fundamental rendering parameters.
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