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Bilayer 3D co-culture platform inducing the differentiation of normal fibroblasts into cancer-associated fibroblast like cells: New in vitro source to obtain cancer-associated fibroblasts.
Bioeng Transl Med
January 2025
Department of Chemical and Biomolecular Engineering Yonsei University Seoul South Korea.
This study presents a novel in vitro bilayer 3D co-culture platform designed to obtain cancer-associated fibroblasts (CAFs)-like cells. The platform consists of a bilayer hydrogel structure with a collagen/polyethylene glycol (PEG) hydrogel for fibroblasts as the upper layer and an alginate hydrogel for tumor cells as the lower layer. The platform enabled paracrine interactions between fibroblasts and cancer cells, which allowed for selective retrieval of activated fibroblasts through collagenase treatment for further study.
View Article and Find Full Text PDFRecent Research on Chondrocyte Dedifferentiation and Insights for Regenerative Medicine.
Biotechnol Bioeng
December 2024
Department of Joint Surgery, The First Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Chondrocytes maintain the balance of the extracellular matrix by synthesizing glycoproteins, collagen, proteoglycans and hyaluronic acid. Chondrocyte dedifferentiation refers to a process in which chondrocytes lose their mature differentiated phenotype and transform into a fibroblast-like morphology with fewer differentiated stages and inferior function under external stimulation. The important mechanism of homeostasis loss in osteoarthritis (OA) is a change in the chondrocyte phenotype.
View Article and Find Full Text PDFSerum Galectin-3 Level in Patients with Rheumatoid Arthritis: A Systematic Review and Meta-analysis.
Iran J Allergy Asthma Immunol
October 2024
Research Center for Chronic Inflammatory Diseases, Tehran University of Medical Sciences, Tehran, Iran AND Rheumatology Research Center, Tehran University of Medical Sciences, Tehran, Iran.
Rheumatoid arthritis (RA) is a chronic inflammatory disease characterized by synovial tissue transformation and fibroblast-like synoviocyte (FLS) proliferation. Galectin-3 is gaining attention as a diagnostic and prognostic biomarker for RA diagnosis. Elevated levels of Galectin-3 cause RA-FLSs to stimulate and generate proinflammatory agents, contributing to cartilage degradation and osteoclast formation.
View Article and Find Full Text PDFDetection and Characterization of Multidimensional Information of Adipocyte Model Based on AFM-Raman.
Microsc Res Tech
November 2024
International Research Centre for Nano Handling and Manufacturing of China, Changchun University of Science and Technology, Changchun, China.
Excessive accumulation of white adipose tissue leads to metabolic disorders, and the excessive differentiation of preadipocytes into white adipocytes is one of the contributing factors to obesity. The browning of white adipocytes has been regarded as a promising therapeutic strategy. To analyze the origins and potential solutions for obesity from a fundamental perspective, we employed atomic force microscopy, and Raman confocal microscopy to investigate and characterize multidimensional information regarding the differentiation process of 3 T3-L1 preadipocyte models into white adipocytes and their subsequent browning into beige adipocytes.
View Article and Find Full Text PDFAnnexin A2 promotes proliferative vitreoretinopathy in response to a macrophage inflammatory signal in mice.
Nat Commun
October 2024
Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA.
Article Synopsis
- * In this condition, retinal pigment epithelial cells lose their anchor to a supportive membrane, become more mobile, and migrate to the retinal surface, which can worsen vision.
- * Research indicates that annexin A2 plays a key role in this process by aiding the movement of these retinal cells when stimulated by specific inflammatory proteins, and targeting these proteins in mice may help reduce the condition's progression.
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