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Sex Differences in Long COVID.
JAMA Netw Open
January 2025
University Hospitals Cleveland Medical Center, Case Western Reserve University School of Medicine, Cleveland, Ohio.
Importance: A substantial number of individuals worldwide experience long COVID, or post-COVID condition. Other postviral and autoimmune conditions have a female predominance, but whether the same is true for long COVID, especially within different subgroups, is uncertain.
Objective: To evaluate sex differences in the risk of developing long COVID among adults with SARS-CoV-2 infection.
Characterisation of older patients that require, but do not undergo, emergency laparotomy: a multicentre cohort study.
Br J Anaesth
November 2024
University of Glasgow, Glasgow, UK; Department of Surgery, Royal Alexandra Hospital, Paisley, UK. Electronic address:
Article Synopsis
- Older adults (65+) represent a significant portion of emergency laparotomy cases in the UK, yet there's limited data on patients who require surgery but do not undergo it, referred to as NoLap patients.
- A study across 64 surgical centers tracked 750 NoLap patients over a 90-day period and found that 60% were female with a median age of 83, most suffering from frailty and severe comorbidities, leading to a high 90-day mortality rate of 79%.
- The findings highlight the complex medical challenges faced by NoLap patients, with a small percentage surviving long-term but requiring increased care, emphasizing the need for further research on the decision-making process surrounding surgery in this high-risk group.
Return of genetic research results in 21,532 individuals with autism.
Genet Med
October 2024
Division of Genetics and Genomics, Department of Pediatrics, Boston Children's Hospital, Boston, MA; Department of Pediatrics, Harvard Medical School, Boston, MA. Electronic address:
Purpose: The aim of this study is to identify likely pathogenic (LP) and pathogenic (P) genetic results for autism that can be returned to participants in SPARK (SPARKforAutism.org): a large recontactable cohort of people with autism in the United States. We also describe the process to return these clinically confirmed genetic findings.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to create a new prognostic model to estimate the risk of pulmonary complications after elective surgery, which is the leading cause of post-surgery death.
- Data from a large international cohort of over 86,000 patients was used, applying machine learning techniques to identify risk factors for complications like pneumonia and respiratory distress.
- The model, named the GSU-Pulmonary Score, was validated with additional cohorts and is available as an online tool to assist in patient care and resource management, especially important during pandemic recovery.
Adding 6 months of androgen deprivation therapy to postoperative radiotherapy for prostate cancer: a comparison of short-course versus no androgen deprivation therapy in the RADICALS-HD randomised controlled trial.
Lancet
June 2024
MRC Clinical Trials Unit at UCL, Institute of Clinical Trials and Methodology, University College London, London, UK. Electronic address:
Article Synopsis
- A clinical trial called RADICALS-HD studied the effects of adding short-course androgen deprivation therapy (ADT) to postoperative radiotherapy in patients with localized prostate cancer after surgery.
- It involved 1480 patients, examining how ADT impacts metastasis-free survival compared to radiotherapy alone, and measured outcomes like distant metastasis and overall survival.
- The trial aimed to see if combining ADT with radiotherapy could improve the 10-year metastasis-free survival rate, potentially increasing it from 80% to 86%.
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