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Low-molecular-weight Ligand of the Thyroid-stimulating Hormone Receptor with the Activity of a Partial Agonist and a Negative Allosteric Modulator.
Dokl Biochem Biophys
January 2025
I.M. Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia.
Graves' disease is caused by overactivation of the thyroid-stimulating hormone receptor (TSHR). One approach for its treatment may be the use of negative allosteric modulators (NAM) of TSHR, which normalize TSHR activity and do not cause thyroid hormone (TH) deficiency. The aim of the work was to study the effect of a new compound 5-amino-4-(4-bromophenyl)-2-(methylthio)thieno[2,3-d]pyrimidine-6-carboxylic acid N-tert-butylamide (TPY4) on the basal and TSH-stimulated TH production in cultured FRTL-5 thyrocytes and on basal and thyrotropin-releasing hormone (TRH)-stimulated TH levels in the blood of rats.
View Article and Find Full Text PDFIdentification of a Biosynthetic Gene Cluster for the Production of the Blue-Green Pigment Xylindein by the Fungus .
J Nat Prod
January 2025
Fungal Natural Products Group, Westerdijk Fungal Biodiversity Institute, 3584 CT Utrecht, Netherlands.
Xylindein is a blue-green pigment produced by the fungi and Its stunning color and optoelectronic properties make xylindein valuable for textiles and as a natural semiconductor material. However, producing xylindein from culture broths remains challenging because of the slow growth of the species and the poor solubility of xylindein in organic solvents. An alternative production route for obtaining pure xylindein is heterologous expression of the xylindein biosynthetic genes.
View Article and Find Full Text PDFTurkish adaptation and psychometric evaluation of the Grief Impairment Scale.
Death Stud
January 2025
Necmettin Erbakan University, Konya, Turkey.
ABSRACTGrief usually proceeds in a normal course, but sometimes it may become dysfunctional. So psychometrically robust assessments are needed to identify abnormal grief. This study aimed to adapt the Grief Impairment Scale to Turkish and explore its psychometric properties with a sample of 364 bereaved adults.
View Article and Find Full Text PDFKnitted stockings were one of the most important early modern textile innovations. Especially fine stockings made of silk were a popular fashion product and one of the key novelties among European elites. The popularity of knitted stockings is seen in the fact that by the end of the fifteenth century, there were thousands of professional knitters in Europe.
View Article and Find Full Text PDFComparative analysis of pediatric SHH medulloblastoma DAOY spheres and adherent monolayers: implications for medulloblastoma research.
Cancer Cell Int
January 2025
Institute of Molecular Genetics of the Czech Academy of Sciences, Vídeňská 1083, Prague 4, 142 20, Czech Republic.
Medulloblastoma, the most prevalent brain tumor among children, requires a comprehensive understanding of its cellular characteristics for effective research and treatment. In this study, we focused on DAOY, a permanent cell line of medulloblastoma, and investigated the unique properties of DAOY cells when cultured as floating multicellular aggregates called spheres, as opposed to adherent monolayers. Through our comprehensive analysis, we identified distinct characteristics associated with DAOY spheres.
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