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Quantifying conformational changes in the TCR:pMHC-I binding interface.
Front Immunol
December 2024
Koohy Lab, Medical Research Council Translational Immune Discovery Unit (MRC TIDU), Weatherall Institute of Molecular Medicine (WIMM), Radcliffe Department of Medicine, University of Oxford, Oxford, United Kingdom.
Background: T cells form one of the key pillars of adaptive immunity. Using their surface bound T cell antigen receptors (TCRs), these cells screen millions of antigens presented by major histocompatibility complex (MHC) or MHC-like molecules. In other protein families, the dynamics of protein-protein interactions have important implications for protein function.
View Article and Find Full Text PDFMolecular Dynamics Simulations Reveal How Competing Protein-Surface Interactions for Glycine, Citrate, and Water Modulate Stability in Antibody Fragment Formulations.
Mol Pharm
November 2024
Department of Biochemical Engineering, University College London, Gower Street, London WC1E 6BT, U.K.
The design of stable formulations remains a major challenge for protein therapeutics, particularly the need to minimize aggregation. Experimental formulation screens are typically based on thermal transition midpoints (), and forced degradation studies at elevated temperatures. Both approaches give limited predictions of long-term storage stability, particularly at low temperatures.
View Article and Find Full Text PDFImmunogenicity and Neutralization Potential of Recombinant Chimeric Protein Comprising the Catalytic Region of Gp63 of and LTB against .
Protein Pept Lett
December 2024
Gene Regulation Laboratory, National Institute of Immunology, New Delhi, 110067, India.
Aim: To study the inhibition potential of antibody against a recombinant chimera comprising of the catalytic epitope of gp63 of and B subunit of heat-labile enterotoxin (LTB) in the functional activity of L. donovani.
Background: Visceral leishmaniasis, caused by the protozoan parasite , is a major health problem and causes mortality in tropical regions.
A Comparison of Natural and Therapeutic Anti-IgE Antibodies.
Antibodies (Basel)
July 2024
Department of Rheumatology and Immunology, University Hosptial of Bern, 3010 Bern, Switzerland.
Article Synopsis
- Immunoglobulin E (IgE) is crucial for fighting off parasites, toxins, and cancer but can cause allergic reactions like anaphylaxis when misregulated.
- Effector cells such as basophils and mast cells, which display IgE, initiate these reactions through degranulation when triggered by allergens.
- Therapeutic monoclonal antibodies like omalizumab are used to manage IgE-related conditions, and recent studies suggest naturally occurring anti-IgE autoantibodies may help regulate IgE activity, highlighting potential therapeutic insights.
Molecular basis for non-invasive diagnostics of cardiac amyloids using bone tracers.
Biomater Sci
August 2024
Department of Pharmacology, Physiology & Biophysics, Boston University Chobanian and Avedisian School of Medicine, Boston, MA, USA.
Amyloid diseases including Alzheimer's, Parkinson's and over 30 others are incurable life-threatening disorders caused by abnormal protein deposition as fibrils in various organs. Cardiac amyloidosis is particularly challenging to diagnose and treat. Identification of the fibril-forming protein, which in the heart is usually amyloid transthyretin (ATTR) or amyloid immunoglobulin light chain (AL), is paramount to treatment.
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