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Limited usefulness of the IS touchdown-PCR in blood for tuberculin skin test false-negative cattle with serological response to .
Front Vet Sci
May 2024
Instituto de Agrobiotecnología y Biología Molecular (IABiMo) UEDD CONICET-INTA, Centro de Investigación en Ciencias Veterinarias y Agronómicas (CICVyA)-CNIA, Hurlingham, Argentina.
Ante-mortem diagnosis of bovine tuberculosis (bTB) is based mainly on the tuberculin skin test (TST) and the ɣ-IFN release assay (IGRA). Some infected animals escape screening tests, thus, limit herd sanitation. Previous reports have suggested a predominant pattern of multi-organ lesions attributable to (the causative agent of bTB) bacteraemia.
View Article and Find Full Text PDFTuberculosis-Associated Hemophagocytic Lymphohistiocytosis: Diagnostic Challenges and Determinants of Outcome.
Open Forum Infect Dis
April 2024
Department of Internal Medicine and Radboud Center for Infectious Diseases, Radboud University Medical Center, Nijmegen, the Netherlands.
Background: Tuberculosis (TB) can induce secondary hemophagocytic lymphohistiocytosis (HLH), a severe inflammatory syndrome with high mortality. We integrated all published reports of adult HIV-negative TB-associated HLH (TB-HLH) to define clinical characteristics, diagnostic strategies, and therapeutic approaches associated with improved survival.
Methods: PubMed, Embase, and Global Index Medicus were searched for eligible records.
Differences in PPD- and mitogen-induced T-cell activation marker expression characterize immunopathology in acute tuberculosis patients.
Eur J Clin Microbiol Infect Dis
March 2024
Department of General Pediatrics, Neonatology and Pediatric Cardiology, Medical Faculty, University Hospital Duesseldorf, Heinrich-Heine-University, 40225, Duesseldorf, Germany.
Article Synopsis
- - Patients with tuberculosis (TB) exhibit impaired T-cell responses and high expression of T-cell activation markers, particularly among T-cells specific for Mycobacterium tuberculosis.
- - A study involving 60 TB patients and 37 asymptomatic individuals found that TB patients had more CD38+ T-cells but similar overall proportions of PPD-specific T-cells compared to controls.
- - Despite higher CD38 expression, TB patients' T-cells showed reduced responses to mitogens, which enhanced the effectiveness of the TAM-TB assay by using the PPD/PHA-induced T-cell ratio for classification.
Anergy to purified protein derivative and chronic energy deficiency in sputum-positive pulmonary tuberculosis: Dynamic assessment at baseline and treatment completion.
Int J Mycobacteriol
December 2023
Department of Medicine, Christian Medical College, Vellore, Tamil Nadu, India.
Background: Tuberculosis (TB) remains a high burden disease in India. Nutrition plays a pivotal role in holistic recovery of the same.
Methods: Patients with sputum positive pulmonary TB were consecutively recruited into the study aimed to observe the incidence of under nutrition and anergy purified protein derivative (PPD).
Massive generalised lymphadenopathy: a rare presentation of tuberculosis with a favourable outcome.
BMJ Case Rep
March 2023
Department of Respiratory Medicine, Dr D Y Patil Medical College, Hospital and Research center, Dr D Y Patil Vidyapeeth, Pimpri, Pune (Deemed University), Pune, Maharashtra, India.
Article Synopsis
- The case discusses a 30-year-old man with extensive necrotic lymphadenopathy caused by tuberculosis, showing no involvement of solid organs.
- He initially presented with symptoms like weight loss and cough, and a CT scan revealed swollen lymph nodes in the chest and abdomen.
- After confirming TB through a biopsy and treating it with antitubercular medications and steroids for 12 months, he is now symptom-free, has regained weight, and his lymph nodes have significantly improved.
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