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Depressive Symptoms and Amyloid Pathology.
JAMA Psychiatry
January 2025
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Mölndal, Sweden.
Importance: Depressive symptoms are associated with cognitive decline in older individuals. Uncertainty about underlying mechanisms hampers diagnostic and therapeutic efforts. This large-scale study aimed to elucidate the association between depressive symptoms and amyloid pathology.
View Article and Find Full Text PDFEpileptic variant in the spectrum of Alzheimer's disease - practical implications.
Seizure
September 2024
Centre Mémoire, de Ressources et de Recherche de Strasbourg, France; Unité de Neuropsychologie, Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and CNRS, ICube laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), team IMIS/Neurocrypto Strasbourg, France; Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg, France. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is linked to a higher risk of epilepsy, not only in its advanced stages (dementia) but also during earlier phases like mild cognitive impairment.
- Epileptic seizures can even appear in the preclinical stage of AD, leading to a specific condition called the epileptic variant of Alzheimer's disease (evAD), which may be the only visible sign of the disease at that time.
- Diagnosing evAD relies on examining amyloid and tau biomarkers and represents a crucial opportunity for early intervention with antiseizure medications to help slow down cognitive decline associated with AD.
Transient epileptic amnesia: a retrospective cohort study of 127 cases, including CSF amyloid and tau features.
J Neurol
April 2023
Centre Mémoire, de Ressources et de Recherche d'Alsace (Strasbourg-Colmar), Service de Neurologie des Hôpitaux Universitaires de Strasbourg, Pôle Tête et Cou, 1 Avenue Molière, 67200, Strasbourg, France.
Background: Transient epileptic amnesia (TEA) is a late-onset epilepsy syndrome encompassing transient iterative amnesias and interictal cognitive impairment, two features that overlap with incipient neurodegenerative dementias. We, therefore, examined the yield of CSF amyloid and tau biomarkers in TEA.
Methods: In this retrospective study, 127 TEA patients with unremarkable imaging findings were divided into 2 groups, namely, CSF (n = 71) and no-CSF (n = 56).
Georges Perec's memoir of his analysis, "The Scene of a Stratagem" (1977), is part of a literary oeuvre characterized by innovative forms addressing the paradoxical task of telling a story that cannot be told. His life history was constructed from memory traces, veiled behind the untimely death of his parents in World War II. The memoir tells the story of his analysis in adulthood with Jean-Bertrand Pontalis, at a time when Perec was struggling with depression and writer's block.
View Article and Find Full Text PDFTransient epileptic amnesia is significantly associated with discrete CA1-located hippocampal calcifications but not with atrophic changes on brain imaging.
Epilepsy Res
October 2021
Centre Mémoire, de Ressources et de Recherche d'Alsace (Strasbourg-Colmar), France; Unité de Neuropsychologie, Service de Neurologie et hôpital de jour de Gériatrie, pôle de Gériatrie, Hôpitaux Universitaires de Strasbourg, Strasbourg, France; University of Strasbourg and CNRS, ICube Laboratory UMR 7357 and FMTS (Fédération de Médecine Translationnelle de Strasbourg), Team IMIS/Neurocrypto Strasbourg, France; Centre de Compétences des démences rares des Hôpitaux Universitaires de Strasbourg, France. Electronic address:
Background: The exact etiology of transient epileptic amnesia (TEA) is currently unknown. In older individuals, common neurodegenerative dementias and small-vessel diseases (SVDs) could be major contributors. We examined these hypotheses on the basis of imaging analysis.
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