AI Article Synopsis
- An outbreak of a urinary tract infection in a hospital was caused by a unique strain of Proteus rettgeri that could ferment lactose and was resistant to all tested antibiotics.
- The strain showed differences in its O antigen compared to the normal type and was sensitive to serum but caused kidney inflammation and temporary bacteria in the urine in rats.
- Despite efforts to transfer its traits to E. coli strains, the attempts failed, and the source of the infection could not be identified, suggesting it spread from outside the hospital.
Article Abstract
An outbreak of nosocomial urinary-tract infection was caused by a strain of Proteus rettgeri that fermented lactose overnight and was resistant to all antimicrobial drugs tested. The nonmotile isolates shared an O (somatic) antigen that differed from those of wild-type P. rettgeri. The organisms proved markedly serum-sensitive. In rats, the isolates elicited an acute interstitial nephritis with associated transient bacteriuria. Attempts to transfer the lac(+) trait and drug-resistance markers to recipient strains of Escherichia coli K-12 failed; exposure of the isolates to acridine orange yielded small numbers of non-lactose-fermenting variants which, however, were still as drug-resistant as before. Epidemiological studies failed to uncover the source of this unique strain and appeared to indicate exogenous spread of infection.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC376299 | PMC |
| http://dx.doi.org/10.1128/am.22.3.278-283.1971 | DOI Listing |
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