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Effects of a scoring aid on glasgow coma score assessment and physicians' comprehension: a simulator-based randomized clinical trial.
J Neurol
December 2024
Clinic for Intensive Care Medicine, University Hospital Basel, Basel, Switzerland.
Purpose: Examining the impact of scoring aids on the accuracy of assessing the Glasgow Coma Score (GCS) in a standardized trauma scenario (primary outcome). Evaluating physicians' understanding of the GCS assessment and clinical application (secondary outcome).
Materials And Methods: This randomized trial was performed at the simulator center of a Swiss tertiary academic medical hospital.
Questionnaire on sustainability practices in French rhythmology departments.
Arch Cardiovasc Dis
November 2024
Cardiology Department, Grenoble Alpes University, Grenoble Alpes University Hospital, 38043 Grenoble, France.
Background: On the one hand, climate change affects health and healthcare systems worldwide. On the other hand, the healthcare system contributes to environmental pollution. These environmental issues concern rhythmology, particularly because of the use of complex, often plastic, single-use devices.
View Article and Find Full Text PDFAdvance directives in the intensive care unit: An eight-year vanguard cohort study.
J Crit Care
February 2025
Intensive Care Unit, Department of Acute Medicine, University Hospital Basel, Basel, Switzerland; Medical faculty of the University of Berne, Berne, Switzerland. Electronic address:
Purpose: To investigate the frequency, content, and clinical translation of advance directives in intensive care units (ICUs).
Material And Methods: Retrospective cohort study in a Swiss tertiary ICU, including patients with advance directives treated in ICUs ≥48 h. The primary endpoint was the violation of directives.
Opioid prescribing requirements to minimize unused medications after an emergency department visit for acute pain: a prospective cohort study.
CMAJ
July 2024
Study Centre in Emergency Medicine (Daoust, Paquet, Huard, Lessard, Cournoyer), Centre intégré universitaire de santé et de services sociaux (CIUSSS) du Nord-de-l'Île de-Montréal, Sacré-Coeur Hospital; Département de médecine de famille et médecine d'urgence (Daoust, Huard, Lessard, Cournoyer), Faculté de médecine, Université de Montréal, Montréal, Que.; Département de médecine de famille et de médecine d'urgence (Émond), Faculté de Médecine, Université Laval; Département d'urgence du CHU-Québec (Émond), Québec, Que.; Department of Emergency Medicine (Iseppon), Hôpital Maisonneuve-Rosemont; Centre de recherche de l'Hôpital du Sacré-Coeur de Montréal (CIUSSS du Nord-de-l'Île-de-Montréal) (Williamson, Lavigne); Faculté de Pharmacie (Williamson), Université de Montréal, Montréal, Que.; Division of Emergency Medicine (Yan), Department of Medicine, Western University, London Health Sciences Centre, London, Ont.; Department of Emergency Medicine (Perry), University of Ottawa, Ottawa, Ont.; Faculties of Dental Medicine and Medicine (Lavigne), Université de Montréal, Montréal, Que.; Department of Emergency Services and Scientist (Lee), Clinical Epidemiology Unit, Sunnybrook Health Sciences; Schwartz/Reisman Emergency Medicine Institute (Lee), Mount Sinai Hospital, Toronto, Ont.; Department of Emergency Medicine (Lang), Cumming School of Medicine, University of Calgary, Calgary, Alta.
Background: Unused opioid prescriptions can be a driver of opioid misuse. Our objective was to determine the optimal quantity of opioids to prescribe to patients with acute pain at emergency department discharge, in order to meet their analgesic needs while limiting the amount of unused opioids.
Methods: In a prospective, multicentre cohort study, we included consecutive patients aged 18 years and older with an acute pain condition present for less than 2 weeks who were discharged from emergency department with an opioid prescription.
Proton pump inhibitors and cancer treatments: Emerging evidence against coadministration.
Cancer Treat Rev
September 2024
School of Pharmacy, University of Washington, Seattle, USA. Electronic address:
Background: Proton pump inhibitors (PPIs) are widely used in cancer patients despite accumulating data showing that they can impact the efficacy of major anticancer drugs. This is particularly important with tyrosine kinase inhibitors (TKIs) and immune checkpoint inhibitors (CPIs).
Results: Most TKIs require gastric acidity for their absorption and some retrospective series demonstrated that coprescription decreases the survival benefit of some TKI use (erlotinib, gefitinib and pazopanib).
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