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Deferral rate variability in blood donor eligibility assessment.
Transfusion
January 2019
Research Division, Donor Studies Department, Sanquin Blood Supply, Amsterdam, The Netherlands.
Article Synopsis
- The study examined variability in blood donor deferral rates based on the interviewer conducting the health interview, revealing significant differences among them.
- The research involved data from 138,398 donor visits in the Netherlands, using statistical analyses to identify patterns in deferral reasons, particularly highlighting variations in low hemoglobin and other medical deferrals.
- Findings indicate that deferrals are somewhat random but differ significantly by interviewer, suggesting that some interviewers may be more conservative or cautious, calling for improvements in the validity of interview outcomes.
Parental Diabetes Behaviors and Distress Are Related to Glycemic Control in Youth with Type 1 Diabetes: Longitudinal Data from the DINO Study.
J Diabetes Res
August 2018
Department of Medical Psychology, VU University Medical Center, De Boelenlaan 1117, 1081 HV Amsterdam, Netherlands.
Objective: To evaluate (1) the longitudinal relationship between parental well-being and glycemic control in youth with type 1 diabetes and (2) if youth's problem behavior, diabetes parenting behavior, and parental diabetes-distress influence this relationship.
Research Design And Methods: Parents of youth 8-15 yrs (at baseline) ( = 174) participating in the DINO study completed questionnaires at three time waves (1 yr interval). Using generalized estimating equations, the relationship between parental well-being (WHO-5) and youth's HbA1c was examined.
Differential adipokine receptor expression on circulating leukocyte subsets in lean and obese children.
PLoS One
November 2017
Laboratory for Translational Immunology, University Medical Center Utrecht, Utrecht, The Netherlands.
Background: Childhood obesity prevalence has increased worldwide and is an important risk factor for type 2 diabetes (T2D) and cardiovascular disease (CVD). The production of inflammatory adipokines by obese adipose tissue contributes to the development of T2D and CVD. While levels of circulating adipokines such as adiponectin and leptin have been established in obese children and adults, the expression of adiponectin and leptin receptors on circulating immune cells can modulate adipokine signalling, but has not been studied so far.
View Article and Find Full Text PDF[Fever with a rash caused by chronic meningococcemia].
Ned Tijdschr Geneeskd
July 2015
Afd. Kindergeneeskunde: J.C. de Jonge, coassistent kindergeneeskunde; dr. K. Koop, aios kindergeneeskunde; drs. R. Nuboer, kinderarts.
Background: Fever with a rash is a common clinical presentation, which can be caused by various medical conditions.
Case Description: A 14-year old boy presented at the outpatient clinic with a two-week history of fever, myalgia and purpuric skin lesions. Blood cultures showed an infection with Neisseria meningitidis.
Vitamin D deficiency in childhood obesity is associated with high levels of circulating inflammatory mediators, and low insulin sensitivity.
Int J Obes (Lond)
January 2014
1] Department of Pediatric Immunology and Center for Molecular and Cellular Intervention, Wilhelmina Children's Hospital, University Medical Center Utrecht, Utrecht, The Netherlands [2] Department of Metabolic Diseases, University Medical Center Utrecht, Utrecht, The Netherlands.
Hypothesis: Childhood obesity is accompanied by low-grade systemic inflammation, which contributes to the development of insulin resistance and cardiovascular complications later in life. As vitamin D exhibits profound immunomodulatory functions and vitamin D deficiency is highly prevalent in childhood obesity, we hypothesized that vitamin D deficiency in childhood obesity coincides with enhanced systemic inflammation and reduced insulin sensitivity.
Methods: In a cross-sectional study of 64 obese and 32 healthy children aged 6-16 years, comprehensive profiling of 32 circulating inflammatory mediators was performed, together with assessment of 25-hydroxyvitamin D (25(OH)D) levels and measures for insulin sensitivity.
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