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[Vacuum ultraviolet laser dissociation and proteomic analysis of halogenated peptides].
Se Pu
February 2025
CAS Key Laboratory of Separation Sciences for Analytical Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China.
Chemical modifications are widely used in research fields such as quantitative proteomics and interaction analyses. Chemical-modification targets can be roughly divided into four categories, including those that integrate isotope labels for quantification purposes, probe the structures of proteins through covalent labeling or cross-linking, incorporate labels to improve the ionization or dissociation of characteristic peptides in complex mixtures, and affinity-enrich various poorly abundant protein translational modifications (PTMs). A chemical modification reaction needs to be simple and efficient for use in proteomics analysis, and should be performed without any complicated process for preparing the labeling reagent.
View Article and Find Full Text PDFSQSTM1/P62 Mediates the Effects of CPNE3 on the Epithelialmesenchymal Transition and Migratory Inhibition of Lung Adenocarcinoma Cells.
Curr Med Chem
January 2025
Medical Experimental Center, The First People's Hospital of Nanning, The Fifth Affiliated Hospital of Guangxi Medical University, Nanning, 530022, China.
Introduction: Copine-3 (CPNE3) is a conservative calcium-dependent phospholipid-binding protein belonging to the copines protein family. CPNE3 has been implicated in the development and progression of several diseases, including cancer.
Method: Herein, we investigated the molecular mechanisms through which CPNE3 regulates the migration of lung adenocarcinoma (LUAD) cells in vitro.
Abiotic and Biotic Dissipation in Natural Attenuation of Phenanthrene and Benzo[a]pyrene: A Systematic Quantification Study in Contrasting Soils.
Environ Pollut
January 2025
State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210023, China.
Natural attenuation represents a significant ecosystem function for mitigating the quantity and toxicity of polycyclic aromatic hydrocarbons (PAHs) through both abiotic and biotic dissipation processes. This study systematically investigated abiotic and biotic dissipation of phenanthrene (Phe) and benzo[a]pyrene (BaP) in four soils over 360 days, using CSIA to quantitatively analyze δ³C changes and demonstrate biodegradation. The results indicated that extractable Phe was primarily attenuated via biodegradation (65% - 81%), as revealed by CSIA, with the δ³C changes ranging from 2.
View Article and Find Full Text PDFIntegrated Quantitative Tracing for Karst Groundwater Contamination: A Case Study of Landfill in Zunyi, Guizhou Province, China.
Environ Pollut
January 2025
114 Geological Brigade of Guizhou Geological and Mineral Exploration and Development Bureau, Zunyi, 563000, China; Karst Water Resources and Environment Academician Workstation of Guizhou Province, Zunyi 563000, China.
Sudden groundwater pollution in karst areas poses a serious threat to drinking water safety. Tracing contamination sources is crucial for managing and remediating groundwater pollution. Traditional tracing methods often lack accuracy, so this study combined multiple techniques to trace and quantify pollution sources near the municipal solid waste (MSW) landfill in Zunyi City, Guizhou Province, China.
View Article and Find Full Text PDFSILAC-based quantification reveals modulation of the immunopeptidome in BRAF and MEK inhibitor sensitive and resistant melanoma cells.
Front Immunol
January 2025
Rudolf Virchow Center, Center for Integrative and Translational Bioimaging, Julius-Maximilians-Universität of Würzburg, Würzburg, Germany.
Background: The immunopeptidome is constantly monitored by T cells to detect foreign or aberrant HLA peptides. It is highly dynamic and reflects the current cellular state, enabling the immune system to recognize abnormal cellular conditions, such as those present in cancer cells. To precisely determine how changes in cellular processes, such as those induced by drug treatment, affect the immunopeptidome, quantitative immunopeptidomics approaches are essential.
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