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Polydatin retards the progression of osteoarthritis by maintaining bone metabolicbalance and inhibiting macrophage polarization.
Front Bioeng Biotechnol
January 2025
The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, China.
Background: Polydatin (PD), also known as tiger cane glycoside, is a natural compound extracted from the Japanese knotweed plant, which is often referred to as white resveratrol. It exhibits anti-inflammatory, antioxidant, and anti-apoptotic effects in the treatment of various diseases. However, the potential molecular mechanisms of PD in osteoarthritis have not been clearly elucidated.
View Article and Find Full Text PDFFlexible Eyelid Pressure and Motion Dual-Mode Sensor Using Electric Breakdown-Induced Piezoresistivity and Electrical Potential Sensing.
ACS Appl Mater Interfaces
January 2025
Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Sciences Key Lab, Beijing 100730, China.
Multiple ocular surface disorders are associated with the mechanical properties of the interface between the eyelid and cornea. Determining eyelid pressure is vital for diagnosing and preventing these disorders. However, current measurements rely on flat piezoresistive pressure sensor arrays that lack eye-motion sensing capabilities, resulting in discomfort and measurement inaccuracies.
View Article and Find Full Text PDFObesity increases DNA damage in the breast epithelium.
Breast Cancer Res
January 2025
Department of Cancer Biology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157, USA.
Obesity is a modifiable risk factor for breast cancer. Yet, how obesity contributes to cancer initiation is not fully understood. The goal of this study was to determine if the body mass index (BMI) and metabolic hallmarks of obesity are related to DNA damage in normal breast tissue.
View Article and Find Full Text PDFImpact of sodium alginate hydrogel containing bacteriophage peptides that specifically bind to the EtCab protein on the inhibition of Eimeria tenella infection.
Vet Res
January 2025
College of Veterinary Medicine, Northeast Agricultural University, Harbin, China.
Avian coccidiosis, caused by the protozoan Eimeria, leads to significant economic losses for the poultry industry. In this study, bacteriophages that specifically bind to the calcium-binding protein (EtCab) of Eimeria tenella were selected using a biopanning process with a pIII phage display library. The recombinant EtCab protein served as the ligand in this selection process.
View Article and Find Full Text PDFExercise training partly ameliorates cardiac dysfunction in mice during doxorubicin treatment of breast cancer.
J Transl Med
January 2025
Department of Biology, University of Turku, Turku, Finland.
Introduction: Doxorubicin is a chemotherapeutic drug used to treat various cancers. Exercise training (ET) can attenuate some cardiotoxic effects of doxorubicin (DOX) in tumor-free animals. However, the ET effects on cardiac function and glucose metabolism in DOX-treated breast cancer models remain unclear.
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