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N-Substituted Aza-Glycine Promotes C8 CO···HN Hydrogen Bonding: A Novel Motif to Design Constrained Peptidomimetic.
Chem Asian J
March 2025
Jawaharlal Nehru Centre for Advanced Scientific Research, New Chemistry Unit, INDIA.
Peptidomimetic modifications enhance their rigidity, cell permeability, and proteolytic stability of peptides, presenting significant promise for drug development. One such modification involves the isosteric replacement of the peptide backbone CαH with a nitrogen (N) atom, resulting in azapeptides. In azapeptides, there are two backbone N atoms within a single residue, with the possibility of substituting either one or both simultaneously.
View Article and Find Full Text PDFRadical Chemistry of Tetrazenes: Access to Polymers with Pristine Tetrazenyl Chain Ends and Depolymerization Applications.
Angew Chem Int Ed Engl
March 2025
Université Claude Bernard Lyon 1: Universite Claude Bernard Lyon 1, LHCEP, 43 bd du 11 novembre 1918, 69616, Villeurbanne, FRANCE.
We report the first radical reaction of tetrazenes - i. e. functions with four consecutive nitrogen atoms with a linear N-N=N-N chain - that retains the characteristic 4N pattern.
View Article and Find Full Text PDFpath-integral simulations of hydrogen-isotope diffusion in face-centred cubic metals.
J Phys Condens Matter
March 2025
Center for Computational Science and E-Systems, Japan Atomic Energy Agency, 148-4 Kashiwanoha Campus, 178-4 Wakashiba, Kashiwa, Chiba, 277-0871, JAPAN.
Lighter isotopes typically diffuse faster than heavier isotopes; however, the case is not necessarily true for H. Predicting the kinetics of H isotope transport and reactions in substances remains a fundamental challenge in material and condensed matter physics. The peculiar experimentally observed isotope effect on H diffusivities in face-centred cubic (fcc) metals has long been an unresolved problem.
View Article and Find Full Text PDFSynthesis of Selectively 13C/2H/15N-Labelled Arginine to Probe Protein Conformation and Interaction by NMR Spectroscopy.
Chemistry
March 2025
University of Vienna, Institute of Organic Chemistry, W�hringerstrasse 38, 1090, Wien, AUSTRIA.
The charged arginine side chain is unique in determining many innate properties of proteins, contributing to stability and interaction surfaces, and directing allosteric regulation and enzymatic catalysis. NMR experiments can be used to reveal these processes at the molecular level, but it often requires selective insertion of carbon-13, nitrogen-15 and deuterium at defined atomic positions. We introduce a method to endow arginine residues with defined isotope patterns, combining synthetic organic chemistry and cell-based protein overexpression.
View Article and Find Full Text PDFSmall but mighty: the power of microcrystals in structural biology.
IUCrJ
May 2025
Living Systems Institute, University of Exeter, Stocker Road, Exeter EX4 4QD, United Kingdom.
Advancements in macromolecular crystallography, driven by improved sources and cryocooling techniques, have enabled the use of increasingly smaller crystals for structure determination, with microfocus beamlines now widely accessible. Initially developed for challenging samples, these techniques have culminated in advanced beamlines such as VMXm. Here, an in vacuo sample environment improves the signal-to-noise ratio in X-ray diffraction experiments, and thus enables the use of submicrometre crystals.
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