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Correlation of chronic atrophic gastritis with gastric-specific circulating biomarkers.
Arab J Gastroenterol
February 2024
Department of Gastroenterology, No.971 Hospital of People's Liberation Army Navy, Qingdao, Shandong 266071, China. Electronic address:
Background And Study Aims: It has been suggested that the combined detection of multiple serum biomarkers can effectively screen out the high-risk population of chronic atrophic gastritis in the general population. Therefore, it is necessary to establish an effective predictive model of chronic atrophic gastritis.
Patients And Methods: Serum biopsies were assessed using five stomach-specific circulating biomarkers pepsinogen I (PGI), PGII, PGI/II ratio, anti- H.
Urinary Proteomics for Discovery of Gastric Cancer Biomarkers to Enable Precision Clinical Oncology.
OMICS
August 2023
Manipal Academy of Higher Education (MAHE), Manipal, India.
For precision in clinical oncology practice, detection of tumor-derived peptides and proteins in urine offers an attractive and noninvasive alternative for diagnostic or screening purposes. In this study, we report comparative quantitative proteomic profiling of urine samples from patients with gastric cancer and healthy controls using tandem mass tags-based multiplexed mass spectrometry approach. We identified 1504 proteins, of which 246 were differentially expressed in gastric cancer cases.
View Article and Find Full Text PDFAdhesion GPCR GPR56 Expression Profiling in Human Tissues.
Cells
December 2021
Research Laboratories and Clinic of Visceral, Transplantation, Thoracic, and Vascular Surgery, Leipzig University and University Hospital Leipzig, 04103 Leipzig, Germany.
Despite the immense functional relevance of GPR56 (gene ) in highly diverse (patho)physiological processes such as tumorigenesis, immune regulation, and brain development, little is known about its exact tissue localization. Here, we validated antibodies for GPR56-specific binding using cells with tagged GPR56 or eliminated in immunotechniques. Using the most suitable antibody, we then established the human GPR56 tissue expression profile.
View Article and Find Full Text PDFBlood biomarkers for early diagnosis of oesophageal cancer: a systematic review.
Eur J Gastroenterol Hepatol
March 2018
Cancer Epidemiology and Health Services Research Group, Centre for Public Health.
Background: Oesophageal cancer prognosis remains poor owing to the inability to detect the disease at an early stage. Nontissue (serum, urinary or salivary) biomarkers potentially offer less invasive methods to aid early detection of oesophageal cancer. We aimed to systematically review studies assessing the relationship between nontissue biomarkers and subsequent development of oesophageal cancer.
View Article and Find Full Text PDFBiomarkers for Helicobacter pylori infection and gastroduodenal diseases.
Biomark Med
July 2015
Department of Environmental & Preventive Medicine, Oita University Faculty of Medicine, Yufu City, Oita, Japan.
Helicobacter pylori infection is a major cause of gastric cancer. Although identifying H. pylori infected subjects is the first approach for delineating the high-risk population for gastric cancer, the presence of H.
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