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Physiological arterial pressure improves renal performance during normothermic machine perfusion in a porcine kidney DCD model.
Heliyon
January 2025
Division of HPB and Transplant Surgery, Department of Surgery, Transplant Institute, Erasmus Medical Center, Rotterdam, the Netherlands.
Background: Normothermic machine perfusion (NMP) provides a platform for kidney quality assessment. Donation after circulatory death (DCD) donor kidneys are associated with great ischemic injury and high intrarenal resistance (IRR). This experimental study aims to investigate the impact of different perfusion pressures on marginal kidney function and injury during NMP.
View Article and Find Full Text PDFSimulated microgravity predisposes kidney to injury through promoting intrarenal artery remodeling.
FASEB J
January 2025
Department of Nephrology, State Key Laboratory of Kidney Diseases, Beijing Key Laboratory of Kidney Disease Research, National Clinical Research Center for Kidney Diseases, Nephrology Institute of the Chinese People's Liberation Army, Chinese PLA General Hospital, Beijing, China.
Spaceflight-induced multi-organ dysfunction affects the health of astronauts and the safety of in-orbit flight. However, the effect of microgravity on the kidney and the underlying mechanisms are unknown. In the current study, we used a hindlimb unweighting (HU) animal model to simulate microgravity and employed histological analysis, ischemia-reperfusion experiments, renal ultrasonography, bioinformatics analysis, isometric force measurement, and other molecular experimental settings to evaluate the effects of microgravity on the kidneys and the underlying mechanisms involved in this transition.
View Article and Find Full Text PDFEndoscopic Combined Intrarenal Surgery for a Large Stone in a Rare Fused Supernumerary Kidney.
Cureus
December 2024
Urology, Hospital General Dr. Agustín O'Horán, Mérida, MEX.
A supernumerary kidney is a rare birth defect where an extra kidney is present. This extra kidney has its own separate outer covering, blood supply, and collection system. Normally, percutaneous nephrolithotomy (PCNL) is the treatment of choice for large kidney stones, but its ideal use for supernumerary kidneys is unknown.
View Article and Find Full Text PDFPropagation of pathologic α-synuclein from kidney to brain may contribute to Parkinson's disease.
Nat Neurosci
January 2025
Department of Neurology, Renmin Hospital of Wuhan University, Wuhan, China.
Article Synopsis
- The aggregation of α-synuclein (α-Syn) in peripheral organs, particularly the kidneys, is suggested to initiate the spread of Lewy body diseases (LBDs) like Parkinson's disease (PD) to the brain.
- Research indicates that chronic renal failure may lead to increased α-Syn deposits in both the kidneys and brain of affected individuals, possibly explaining the higher incidence of PD in these patients.
- Experiments in mice show that the kidney plays a role in clearing α-Syn from the blood, and renal damage can enhance its deposition in the kidney and subsequent propagation to the brain, highlighting the kidney's potential role in the pathogenesis of LBDs.
Abnormal Venous Flow in Pregnant Women with Mild Right Ventricular Dysfunction in Repaired Tetralogy of Fallot: A Clinical Model for Organ Dysfunction in Preeclampsia.
J Clin Med
December 2024
Department of Cardiology, University Medical Center Groningen, University of Groningen, 9700 RB Groningen, The Netherlands.
Pregnant women with congenital heart disease carry a high risk of complications, especially when cardiac function is suboptimal. Increasing evidence suggests that impaired right ventricular (RV) function has a negative effect on placental function, possibly through venous congestion. We report a case series of hepatic and renal venous flow patterns in pregnant women with right ventricular dysfunction after repaired Tetralogy of Fallot (ToF), relative to those observed in normal pregnancy and preeclampsia.
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