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Unveiling the Origin of Copper Accumulation in Plasma with Aging.
Environ Health (Wash)
January 2025
State Key Laboratory of Environmental Chemistry and Ecotoxicology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China.
Aging is intricately linked to various diseases including cancers, neurodegenerative disorders, and metabolic irregularities. Copper (Cu) overexposure has been found to be linked to many diseases during aging, particularly neurodegenerative diseases. Meanwhile, as an essential element, Cu has been implicated in key processes associated with aging, raising questions about its role in age-related health issues.
View Article and Find Full Text PDFA comparative analysis in monitoring 24-hour urinary copper in wilson disease: sampling on or off treatment?
Orphanet J Rare Dis
January 2025
Internal Medicine IV, Department of Gastroenterology, University Hospital Heidelberg, INF 410, Heidelberg, 69120, Germany.
Background & Aim: Twenty-four-hour urinary copper excretion (24 h-UCE) is the standard diagnostic tool for dose adjustments in maintenance therapy in Wilson disease (WD) patients. Guidelines lack data if both variants of 24 h-UCE measurement (with or without 48 h of treatment interruption) are equally interpretable.
Methods: Eighty-four patients with a confirmed diagnosis of WD treated with chelators (50% of patients with D-Penicillamine and 50% with trientine) and with pairwise 24-h-UCE values on-therapy and off-therapy were included in the analysis.
Immobilized Saccharomyces cerevisiae viable cells for electrochemical biosensing of Cu(II).
Sci Rep
January 2025
Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute, University of Nottingham Ningbo China, Ningbo, China.
Electrodes functionalised with weak electroactive microorganisms offer a viable alternative to conventional chemical sensors for detecting priority pollutants in bioremediation processes. Biofilm-based biosensors have been proposed for this purpose. However, biofilm formation and maturation require 24-48 h, and the microstructure and coverage of the electrode surface cannot be controlled, leading to poorly reproducible signal and sensitivity.
View Article and Find Full Text PDFThe effect of consuming bread contaminated with heavy metals on cardiovascular disease and calculating its risk assessment.
Sci Rep
January 2025
Department of Environmental Health Engineering, Khalkhal University of Medical Sciences, Khalkhal, Iran.
Heavy metals (HMs) may cause the generation of reactive oxygen species (ROS), which results in oxidative stress and eventually leads to an increase in cardiovascular diseases (CVD). The Hoveyzeh Cohort Study Center provided clinical data for cardiovascular cases. The collection of samples was done randomly.
View Article and Find Full Text PDFIntegrated Quantitative Tracing for Karst Groundwater Contamination: A Case Study of Landfill in Zunyi, Guizhou Province, China.
Environ Pollut
January 2025
114 Geological Brigade of Guizhou Geological and Mineral Exploration and Development Bureau, Zunyi, 563000, China; Karst Water Resources and Environment Academician Workstation of Guizhou Province, Zunyi 563000, China.
Sudden groundwater pollution in karst areas poses a serious threat to drinking water safety. Tracing contamination sources is crucial for managing and remediating groundwater pollution. Traditional tracing methods often lack accuracy, so this study combined multiple techniques to trace and quantify pollution sources near the municipal solid waste (MSW) landfill in Zunyi City, Guizhou Province, China.
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