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Lateral olivocochlear neurons modulate cochlear responses to noise exposure.
Proc Natl Acad Sci U S A
January 2025
Department of Neurobiology, Harvard Medical School, Boston, MA 02115.
The sense of hearing originates in the cochlea, which detects sounds across dynamic sensory environments. Like other peripheral organs, the cochlea is subjected to environmental insults, including loud, damage-inducing sounds. In response to internal and external stimuli, the central nervous system directly modulates cochlear function through olivocochlear neurons (OCNs), which are located in the brainstem and innervate the cochlear sensory epithelium.
View Article and Find Full Text PDFAssessment of distributions and gender difference in adverse events related to faricimab: a real-world study based on FDA adverse event reporting system.
Expert Opin Drug Saf
December 2024
Geriatric Diseases Institute of Chengdu/Cancer Prevention and Treatment Institute of Chengdu, Department of Ophthalmology, Chengdu Fifth People's Hospital (The Second Clinical Medical College, Affiliated Fifth People's Hospital of Chengdu University of Traditional Chinese Medicine), Chengdu, China.
Background: Faricimab is a novel bispecific antibody drug for treating retinal disease. We aim to study the adverse events of faricimab based on the FDA Adverse Event Reporting System (FAERS) database.
Research Design And Methods: The FAERS data from 2020 to 2024 was extracted to conduct disproportionality analysis.
PKHD1L1 is required for stereocilia bundle maintenance, durable hearing function and resilience to noise exposure.
Commun Biol
November 2024
Department of Otolaryngology Head and Neck Surgery, Mass Eye and Ear, Harvard Medical School, Boston, MA, USA.
Article Synopsis
- Polycystic Kidney and Hepatic Disease 1-Like 1 (PKHD1L1) is a gene linked to autosomal recessive deafness (DFNB124) and is essential for the proper functioning of sensory hair cells in the cochlea, which are crucial for hearing.
- The study investigates PKHD1L1 expression in mice throughout various developmental stages and its role in hair-cell bundle structure, revealing that absence of this gene leads to issues with stereocilia starting at 6 weeks of age.
- PKHD1L1-deficient mice exhibit progressive hearing loss with age and are more vulnerable to permanent damage from noise exposure, highlighting the gene's importance in maintaining auditory function during development and against environmental
Severe Neonatal Jaundice (SNJ) causes long-term neurocognitive impairment, cerebral palsy, auditory neuropathy, deafness, or death. We developed a mathematical model for allo-hemodialysis as a potential blood purification method for the treatment of SNJ in term or near-term infants. With allo-hemodialysis (allo-HD), the neonate's blood flows through hollow fibers of a miniature 0.
View Article and Find Full Text PDFCo-release of GABA and ACh from medial olivocochlear neurons fine tunes cochlear efferent inhibition.
bioRxiv
August 2024
Instituto de Investigaciones en Ingeniería Genética y Biología Molecular, "Dr. Héctor N. Torres", Consejo Nacional de Investigaciones Científicas y Técnicas, (1428) Ciudad Autónoma de Buenos Aires, Argentina.
During development, inner hair cells (IHCs) in the mammalian cochlea are unresponsive to acoustic stimuli but instead exhibit spontaneous activity. During this same period, neurons originating from the medial olivocochlear complex (MOC) transiently innervate IHCs, regulating their firing pattern which is crucial for the correct development of the auditory pathway. Although the MOC-IHC is a cholinergic synapse, previous evidence indicates the widespread presence of gamma-aminobutyric acid (GABA) signaling markers, including presynaptic GABA receptors (GABAR).
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